Names & Taxonomy

Uniprot ID:
Q03721
Entry Name:
KCNC4_HUMAN
Status:
reviewed
Protein Names:
Potassium voltage-gated channel subfamily C member 4 (KSHIIIC) (Voltage-gated potassium channel subunit Kv3.4)
Gene Names:
KCNC4
Gene Names Primary:
KCNC4
Organism:
Homo sapiens (Human)

Structure

Length:
635
Sequence:
MISSVCVSSYRGRKSGNKPPSKTCLKEEMAKGEASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGGCRGWQPRMWALFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEILRVGNITSVHFRREVETEPILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKRKKHVPRPAQLESPMYCKSEETSPRDSTCSDTSPPAREEGMIERKRADSKQNGDANAVLSDEEGAGLTQPLASSPTPEERRALRRSTTRDRNKKAAACFLLSTGDYACADGSVRKGTFVLRDLPLQHSPEAACPPTAGTLFLPH
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane; Multi-pass membrane protein.

Function

Function:
This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
Gene Ontology Go:
axon terminus
neuromuscular junction
plasma membrane
voltage-gated potassium channel complex
delayed rectifier potassium channel activity
potassium channel activity
voltage-gated potassium channel activity
potassium ion transport
protein homooligomerization
regulation of neurotransmitter secretion
synaptic transmission
Gene Ontology Biological Process:
potassium ion transport
protein homooligomerization
regulation of neurotransmitter secretion
synaptic transmission
Gene Ontology Molecular Function:
delayed rectifier potassium channel activity
potassium channel activity
voltage-gated potassium channel activity
Gene Ontology Cellular Component:
axon terminus
neuromuscular junction
plasma membrane
voltage-gated potassium channel complex
Keywords:
3D-structure
Alternative splicing
Complete proteome
Glycoprotein
Ion channel
Ion transport
Membrane
Phosphoprotein
Polymorphism
Potassium
Potassium channel
Potassium transport
Reference proteome
Transmembrane
Transmembrane helix
Transport
Voltage-gated channel

Publication

PubMed ID:
1381835 16710414 15489334 7993631 9649584 9000078 10048926