Names & Taxonomy
- Uniprot ID:
- Q03721
- Entry Name:
- KCNC4_HUMAN
- Status:
- reviewed
- Protein Names:
- Potassium voltage-gated channel subfamily C member 4 (KSHIIIC) (Voltage-gated potassium channel subunit Kv3.4)
- Gene Names:
- KCNC4
- Gene Names Primary:
- KCNC4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 635
- Sequence:
- MISSVCVSSYRGRKSGNKPPSKTCLKEEMAKGEASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGGCRGWQPRMWALFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEILRVGNITSVHFRREVETEPILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKRKKHVPRPAQLESPMYCKSEETSPRDSTCSDTSPPAREEGMIERKRADSKQNGDANAVLSDEEGAGLTQPLASSPTPEERRALRRSTTRDRNKKAAACFLLSTGDYACADGSVRKGTFVLRDLPLQHSPEAACPPTAGTLFLPH
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
Function
- Function:
- This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
- Gene Ontology Go:
- axon terminus
neuromuscular junction
plasma membrane
voltage-gated potassium channel complex
delayed rectifier potassium channel activity
potassium channel activity
voltage-gated potassium channel activity
potassium ion transport
protein homooligomerization
regulation of neurotransmitter secretion
synaptic transmission - Gene Ontology Biological Process:
- potassium ion transport
protein homooligomerization
regulation of neurotransmitter secretion
synaptic transmission - Gene Ontology Molecular Function:
- delayed rectifier potassium channel activity
potassium channel activity
voltage-gated potassium channel activity - Gene Ontology Cellular Component:
- axon terminus
neuromuscular junction
plasma membrane
voltage-gated potassium channel complex - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Glycoprotein
Ion channel
Ion transport
Membrane
Phosphoprotein
Polymorphism
Potassium
Potassium channel
Potassium transport
Reference proteome
Transmembrane
Transmembrane helix
Transport
Voltage-gated channel