Names & Taxonomy
- Uniprot ID:
- Q03431
- Entry Name:
- PTH1R_HUMAN
- Status:
- reviewed
- Protein Names:
- Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH/PTHrP type I receptor) (PTH/PTHr receptor) (Parathyroid hormone 1 receptor) (PTH1 receptor)
- Gene Names:
- PTH1R PTHR PTHR1
- Gene Names Primary:
- PTH1R
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 593
- Sequence:
- MGTARIAPGLALLLCCPVLSSAYALVDADDVMTKEEQIFLLHRAQAQCEKRLKEVLQRPASIMESDKGWTSASTSGKPRKDKASGKLYPESEEDKEAPTGSRYRGRPCLPEWDHILCWPLGAPGEVVAVPCPDYIYDFNHKGHAYRRCDRNGSWELVPGHNRTWANYSECVKFLTNETREREVFDRLGMIYTVGYSVSLASLTVAVLILAYFRRLHCTRNYIHMHLFLSFMLRAVSIFVKDAVLYSGATLDEAERLTEEELRAIAQAPPPPATAAAGYAGCRVAVTFFLYFLATNYYWILVEGLYLHSLIFMAFFSEKKYLWGFTVFGWGLPAVFVAVWVSVRATLANTGCWDLSSGNKKWIIQVPILASIVLNFILFINIVRVLATKLRETNAGRCDTRQQYRKLLKSTLVLMPLFGVHYIVFMATPYTEVSGTLWQVQMHYEMLFNSFQGFFVAIIYCFCNGEVQAEIKKSWSRWTLALDFKRKARSGSSSYSYGPMVSHTSVTNVGPRVGLGLPLSPRLLPTATTNGHPQLPGHAKPGTPALETLETTPPAMAAPKDDGFLNGSCSGLDEEASGPERPPALLQEEWETVM
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- This is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.
- Cross Reference Drug Bank:
- DB05829 DB06285
- Gene Ontology Go:
- apical plasma membrane
basolateral plasma membrane
brush border membrane
cytoplasm
cytosol
extracellular exosome
integral component of plasma membrane
nucleus
plasma membrane
receptor complex
parathyroid hormone receptor activity
peptide hormone binding
protein self-association
adenylate cyclase-activating G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
aging
bone mineralization
bone resorption
cell maturation
cell surface receptor signaling pathway
chondrocyte differentiation
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
negative regulation of cell proliferation
osteoblast development
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cell proliferation
positive regulation of cytosolic calcium ion concentration
positive regulation of inositol phosphate biosynthetic process
skeletal system development - Gene Ontology Biological Process:
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
aging
bone mineralization
bone resorption
cell maturation
cell surface receptor signaling pathway
chondrocyte differentiation
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
negative regulation of cell proliferation
osteoblast development
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cell proliferation
positive regulation of cytosolic calcium ion concentration
positive regulation of inositol phosphate biosynthetic process
skeletal system development - Gene Ontology Molecular Function:
- parathyroid hormone receptor activity
peptide hormone binding
protein self-association - Gene Ontology Cellular Component:
- apical plasma membrane
basolateral plasma membrane
brush border membrane
cytoplasm
cytosol
extracellular exosome
integral component of plasma membrane
nucleus
plasma membrane
receptor complex - Keywords:
- 3D-structure
Cell membrane
Complete proteome
Disease mutation
Disulfide bond
Dwarfism
G-protein coupled receptor
Glycoprotein
Membrane
Phosphoprotein
Receptor
Reference proteome
Signal
Transducer
Transmembrane
Transmembrane helix - Interacts With:
- P35222