Names & Taxonomy
- Uniprot ID:
- Q03013
- Entry Name:
- GSTM4_HUMAN
- Status:
- reviewed
- Protein Names:
- Glutathione S-transferase Mu 4 (EC 2.5.1.18) (GST class-mu 4) (GST-Mu2) (GSTM4-4)
- Gene Names:
- GSTM4
- Gene Names Primary:
- GSTM4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 218
- Sequence:
- MSMTLGYWDIRGLAHAIRLLLEYTDSSYEEKKYTMGDAPDYDRSQWLNEKFKLGLDFPNLPYLIDGAHKITQSNAILCYIARKHNLCGETEEEKIRVDILENQAMDVSNQLARVCYSPDFEKLKPEYLEELPTMMQHFSQFLGKRPWFVGDKITFVDFLAYDVLDLHRIFEPNCLDAFPNLKDFISRFEGLEKISAYMKSSRFLPKPLYTRVAVWGNK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Active on 1-chloro-2,4-dinitrobenzene.
- Catalytic Activity:
- RX + glutathione = HX + R-S-glutathione.
- Cross Reference Drug Bank:
- DB00143
- Gene Ontology Go:
- cytoplasm
cytosol
enzyme binding
glutathione binding
glutathione transferase activity
protein homodimerization activity
glutathione derivative biosynthetic process
glutathione metabolic process
nitrobenzene metabolic process
small molecule metabolic process
xenobiotic catabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- glutathione derivative biosynthetic process
glutathione metabolic process
nitrobenzene metabolic process
small molecule metabolic process
xenobiotic catabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- enzyme binding
glutathione binding
glutathione transferase activity
protein homodimerization activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Cytoplasm
Direct protein sequencing
Polymorphism
Reference proteome
Transferase - Interacts With:
- Q6FGJ9