Names & Taxonomy
- Uniprot ID:
- Q02928
- Entry Name:
- CP4AB_HUMAN
- Status:
- reviewed
- Protein Names:
- Cytochrome P450 4A11 (20-hydroxyeicosatetraenoic acid synthase) (20-HETE synthase) (CYP4AII) (CYPIVA11) (Cytochrome P-450HK-omega) (Cytochrome P450HL-omega) (Fatty acid omega-hydroxylase) (Lauric acid omega-hydroxylase) (Long-chain fatty acid omega-monooxygenase) (EC 1.14.13.205)
- Gene Names:
- CYP4A11 CYP4A2
- Gene Names Primary:
- CYP4A11
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 519
- Sequence:
- MSVSVLSPSRLLGDVSGILQAASLLILLLLLIKAVQLYLHRQWLLKALQQFPCPPSHWLFGHIQELQQDQELQRIQKWVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDPKSHGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELLPDPTRIPIPIARLVLKSKNGIHLRLRRLPNPCEDKDQL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Function
- Function:
- Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate, myristate and palmitate. Has little activity toward prostaglandins A1 and E1. Oxidizes arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE).
- Catalytic Activity:
- A long-chain fatty acid + NADPH + O(2) = an omega-hydroxy-long-chain fatty acid + NADP(+) + H(2)O.
- Cofactor:
- COFACTOR: Name=heme; Xref=ChEBI:CHEBI:30413;
- Cross Reference Drug Bank:
- DB00515 DB00636 DB01234 DB00655 DB00898 DB00448 DB00082 DB00738 DB01174 DB01045 DB00755
- Gene Ontology Go:
- apical plasma membrane
cytoplasm
endoplasmic reticulum membrane
extracellular exosome
intracellular membrane-bounded organelle
alkane 1-monooxygenase activity
arachidonic acid epoxygenase activity
heme binding
iron ion binding
leukotriene-B4 20-monooxygenase activity
arachidonic acid metabolic process
cellular lipid metabolic process
epoxygenase P450 pathway
fatty acid metabolic process
leukotriene B4 catabolic process
leukotriene metabolic process
long-chain fatty acid metabolic process
omega-hydroxylase P450 pathway
oxidation-reduction process
positive regulation of icosanoid secretion
pressure natriuresis
renal water homeostasis
small molecule metabolic process
sodium ion homeostasis
xenobiotic metabolic process - Gene Ontology Biological Process:
- arachidonic acid metabolic process
cellular lipid metabolic process
epoxygenase P450 pathway
fatty acid metabolic process
leukotriene B4 catabolic process
leukotriene metabolic process
long-chain fatty acid metabolic process
omega-hydroxylase P450 pathway
oxidation-reduction process
positive regulation of icosanoid secretion
pressure natriuresis
renal water homeostasis
small molecule metabolic process
sodium ion homeostasis
xenobiotic metabolic process - Gene Ontology Molecular Function:
- alkane 1-monooxygenase activity
arachidonic acid epoxygenase activity
heme binding
iron ion binding
leukotriene-B4 20-monooxygenase activity - Gene Ontology Cellular Component:
- apical plasma membrane
cytoplasm
endoplasmic reticulum membrane
extracellular exosome
intracellular membrane-bounded organelle - Keywords:
- Alternative splicing
Complete proteome
Direct protein sequencing
Endoplasmic reticulum
Heme
Iron
Membrane
Metal-binding
Microsome
Monooxygenase
NADP
Oxidoreductase
Polymorphism
Reference proteome