Names & Taxonomy

Uniprot ID:
Q02928
Entry Name:
CP4AB_HUMAN
Status:
reviewed
Protein Names:
Cytochrome P450 4A11 (20-hydroxyeicosatetraenoic acid synthase) (20-HETE synthase) (CYP4AII) (CYPIVA11) (Cytochrome P-450HK-omega) (Cytochrome P450HL-omega) (Fatty acid omega-hydroxylase) (Lauric acid omega-hydroxylase) (Long-chain fatty acid omega-monooxygenase) (EC 1.14.13.205)
Gene Names:
CYP4A11 CYP4A2
Gene Names Primary:
CYP4A11
Organism:
Homo sapiens (Human)

Structure

Length:
519
Sequence:
MSVSVLSPSRLLGDVSGILQAASLLILLLLLIKAVQLYLHRQWLLKALQQFPCPPSHWLFGHIQELQQDQELQRIQKWVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDPKSHGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELLPDPTRIPIPIARLVLKSKNGIHLRLRRLPNPCEDKDQL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Function

Function:
Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate, myristate and palmitate. Has little activity toward prostaglandins A1 and E1. Oxidizes arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE).
Catalytic Activity:
A long-chain fatty acid + NADPH + O(2) = an omega-hydroxy-long-chain fatty acid + NADP(+) + H(2)O.
Cofactor:
COFACTOR: Name=heme; Xref=ChEBI:CHEBI:30413;
Cross Reference Drug Bank:
DB00515 DB00636 DB01234 DB00655 DB00898 DB00448 DB00082 DB00738 DB01174 DB01045 DB00755
Gene Ontology Go:
apical plasma membrane
cytoplasm
endoplasmic reticulum membrane
extracellular exosome
intracellular membrane-bounded organelle
alkane 1-monooxygenase activity
arachidonic acid epoxygenase activity
heme binding
iron ion binding
leukotriene-B4 20-monooxygenase activity
arachidonic acid metabolic process
cellular lipid metabolic process
epoxygenase P450 pathway
fatty acid metabolic process
leukotriene B4 catabolic process
leukotriene metabolic process
long-chain fatty acid metabolic process
omega-hydroxylase P450 pathway
oxidation-reduction process
positive regulation of icosanoid secretion
pressure natriuresis
renal water homeostasis
small molecule metabolic process
sodium ion homeostasis
xenobiotic metabolic process
Gene Ontology Biological Process:
arachidonic acid metabolic process
cellular lipid metabolic process
epoxygenase P450 pathway
fatty acid metabolic process
leukotriene B4 catabolic process
leukotriene metabolic process
long-chain fatty acid metabolic process
omega-hydroxylase P450 pathway
oxidation-reduction process
positive regulation of icosanoid secretion
pressure natriuresis
renal water homeostasis
small molecule metabolic process
sodium ion homeostasis
xenobiotic metabolic process
Gene Ontology Molecular Function:
alkane 1-monooxygenase activity
arachidonic acid epoxygenase activity
heme binding
iron ion binding
leukotriene-B4 20-monooxygenase activity
Gene Ontology Cellular Component:
apical plasma membrane
cytoplasm
endoplasmic reticulum membrane
extracellular exosome
intracellular membrane-bounded organelle
Keywords:
Alternative splicing
Complete proteome
Direct protein sequencing
Endoplasmic reticulum
Heme
Iron
Membrane
Metal-binding
Microsome
Monooxygenase
NADP
Oxidoreductase
Polymorphism
Reference proteome

Publication

PubMed ID:
7679927 7798189 8274222 12464262 16710414 15489334 1739747 8363569 11139583 11821421 15611369 15895287