Names & Taxonomy
- Uniprot ID:
- Q01718
- Entry Name:
- ACTHR_HUMAN
- Status:
- reviewed
- Protein Names:
- Adrenocorticotropic hormone receptor (ACTH receptor) (ACTH-R) (Adrenocorticotropin receptor) (Melanocortin receptor 2) (MC2-R)
- Gene Names:
- MC2R ACTHR
- Gene Names Primary:
- MC2R
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 297
- Sequence:
- MKHIINSYENINNTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLAVFKNKNLQAPMYFFICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLFVLSLLGSIFSLSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTGTGITMVIFSHHVPTVITFTSLFPLMLVFILCLYVHMFLLARSHTRKISTLPRANMKGAITLTILLGVFIFCWAPFVLHVLLMTFCPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKKMIFCSRYW
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Receptor for corticotropin (ACTH). This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase (cAMP).
- Cross Reference Drug Bank:
- DB01285 DB01284
- Gene Ontology Go:
- cytoplasm
integral component of plasma membrane
plasma membrane
corticotropin receptor activity
melanocortin receptor activity
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
neuropeptide signaling pathway
placenta development
positive regulation of cAMP biosynthetic process - Gene Ontology Biological Process:
- G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
neuropeptide signaling pathway
placenta development
positive regulation of cAMP biosynthetic process - Gene Ontology Molecular Function:
- corticotropin receptor activity
melanocortin receptor activity - Gene Ontology Cellular Component:
- cytoplasm
integral component of plasma membrane
plasma membrane - Keywords:
- Cell membrane
Complete proteome
Disease mutation
G-protein coupled receptor
Glycoprotein
Lipoprotein
Membrane
Palmitate
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix