Names & Taxonomy
- Uniprot ID:
- Q01650
- Entry Name:
- LAT1_HUMAN
- Status:
- reviewed
- Protein Names:
- Large neutral amino acids transporter small subunit 1 (4F2 light chain) (4F2 LC) (4F2LC) (CD98 light chain) (Integral membrane protein E16) (L-type amino acid transporter 1) (hLAT1) (Solute carrier family 7 member 5) (y+ system cationic amino acid transporter)
- Gene Names:
- SLC7A5 CD98LC LAT1 MPE16
- Gene Names Primary:
- SLC7A5
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 507
- Sequence:
- MAGAGPKRRALAAPAAEEKEEAREKMLAAKSADGSAPAGEGEGVTLQRNITLLNGVAIIVGTIIGSGIFVTPTGVLKEAGSPGLALVVWAACGVFSIVGALCYAELGTTISKSGGDYAYMLEVYGSLPAFLKLWIELLIIRPSSQYIVALVFATYLLKPLFPTCPVPEEAAKLVACLCVLLLTAVNCYSVKAATRVQDAFAAAKLLALALIILLGFVQIGKGDVSNLDPNFSFEGTKLDVGNIVLALYSGLFAYGGWNYLNFVTEEMINPYRNLPLAIIISLPIVTLVYVLTNLAYFTTLSTEQMLSSEAVAVDFGNYHLGVMSWIIPVFVGLSCFGSVNGSLFTSSRLFFVGSREGHLPSILSMIHPQLLTPVPSLVFTCVMTLLYAFSKDIFSVINFFSFFNWLCVALAIIGMIWLRHRKPELERPIKVNLALPVFFILACLFLIAVSFWKTPVECGIGFTIILSGLPVYFFGVWWKNKPKWLLQGIFSTTVLCQKLMQVVPQET
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, cytosol. Apical cell membrane; Multi-pass membrane protein. Note=Located to the plasma membrane by SLC3A2/4F2hc. Localized to the apical membrane of placental syncytiophoblastic cells. Expressed in both luminal and abluminal membranes of brain capillary endothelial cells (By similarity).
Function
- Function:
- Sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Involved in cellular amino acid uptake. Acts as an amino acid exchanger. Involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Plays a role in neuronal cell proliferation (neurogenesis) in brain. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. May play an important role in high-grade gliomas. Mediates blood-to-retina L-leucine transport across the inner blood-retinal barrier which in turn may play a key role in maintaining large neutral amino acids as well as neurotransmitters in the neural retina. Acts as the major transporter of tyrosine in fibroblasts.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=7.9 uM for T4 (in the presence of choline chloride)
- Cross Reference Drug Bank:
- DB00509 DB01235 DB00451 DB00279 DB01042
- Gene Ontology Go:
- apical plasma membrane
cytoplasm
cytosol
extracellular exosome
integral component of membrane
intracellular membrane-bounded organelle
membrane
plasma membrane
amino acid transmembrane transporter activity
antiporter activity
L-amino acid transmembrane transporter activity
neutral amino acid transmembrane transporter activity
peptide antigen binding
amino acid transport
blood coagulation
cell differentiation
cellular amino acid metabolic process
ion transport
leukocyte migration
nervous system development
neutral amino acid transport
transmembrane transport
transport - Gene Ontology Biological Process:
- amino acid transport
blood coagulation
cell differentiation
cellular amino acid metabolic process
ion transport
leukocyte migration
nervous system development
neutral amino acid transport
transmembrane transport
transport - Gene Ontology Molecular Function:
- amino acid transmembrane transporter activity
antiporter activity
L-amino acid transmembrane transporter activity
neutral amino acid transmembrane transporter activity
peptide antigen binding - Gene Ontology Cellular Component:
- apical plasma membrane
cytoplasm
cytosol
extracellular exosome
integral component of membrane
intracellular membrane-bounded organelle
membrane
plasma membrane - Keywords:
- Amino-acid transport
Cell membrane
Complete proteome
Cytoplasm
Developmental protein
Differentiation
Direct protein sequencing
Disulfide bond
Glycoprotein
Isopeptide bond
Membrane
Neurogenesis
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport
Ubl conjugation