Names & Taxonomy

Uniprot ID:
Q01082
Entry Name:
SPTB2_HUMAN
Status:
reviewed
Protein Names:
Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1)
Gene Names:
SPTBN1 SPTB2
Gene Names Primary:
SPTBN1
Organism:
Homo sapiens (Human)

Structure

Length:
2364
Sequence:
MTTTVATDYDNIEIQQQYSDVNNRWDVDDWDNENSSARLFERSRIKALADEREAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGRMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSNAHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPPSPEPSTKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAETVDTSEMVNGATEQRTSSKESSPIPSPTSDRKAKTALPAQSAATLPARTQETPSAQMEGFLNRKHEWEAHNKKASSRSWHNVYCVINNQEMGFYKDAKTAASGIPYHSEVPVSLKEAVCEVALDYKKKKHVFKLRLNDGNEYLFQAKDDEEMNTWIQAISSAISSDKHEVSASTQSTPASSRAQTLPTSVVTITSESSPGKREKDKEKDKEKRFSLFGKKK
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm, cytoskeleton

Function

Function:
Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
Gene Ontology Go:
axolemma
cuticular plate
cytoplasm
cytosol
extracellular exosome
M band
neuronal postsynaptic density
nucleolus
spectrin
spectrin-associated cytoskeleton
actin binding
ankyrin binding
GTPase binding
phospholipid binding
poly(A) RNA binding
structural constituent of cytoskeleton
actin filament capping
activation of MAPKK activity
axon guidance
cellular protein metabolic process
common-partner SMAD protein phosphorylation
epidermal growth factor receptor signaling pathway
ER to Golgi vesicle-mediated transport
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
Golgi to plasma membrane protein transport
innate immune response
insulin receptor signaling pathway
MAPK cascade
membrane assembly
membrane organization
mitotic cytokinesis
neurotrophin TRK receptor signaling pathway
plasma membrane organization
positive regulation of interleukin-2 secretion
positive regulation of protein localization to plasma membrane
post-translational protein modification
protein N-linked glycosylation via asparagine
protein targeting to plasma membrane
Ras protein signal transduction
regulation of protein localization to plasma membrane
SMAD protein import into nucleus
small GTPase mediated signal transduction
vascular endothelial growth factor receptor signaling pathway
Gene Ontology Biological Process:
actin filament capping
activation of MAPKK activity
axon guidance
cellular protein metabolic process
common-partner SMAD protein phosphorylation
epidermal growth factor receptor signaling pathway
ER to Golgi vesicle-mediated transport
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
Golgi to plasma membrane protein transport
innate immune response
insulin receptor signaling pathway
MAPK cascade
membrane assembly
membrane organization
mitotic cytokinesis
neurotrophin TRK receptor signaling pathway
plasma membrane organization
positive regulation of interleukin-2 secretion
positive regulation of protein localization to plasma membrane
post-translational protein modification
protein N-linked glycosylation via asparagine
protein targeting to plasma membrane
Ras protein signal transduction
regulation of protein localization to plasma membrane
SMAD protein import into nucleus
small GTPase mediated signal transduction
vascular endothelial growth factor receptor signaling pathway
Gene Ontology Molecular Function:
actin binding
ankyrin binding
GTPase binding
phospholipid binding
poly(A) RNA binding
structural constituent of cytoskeleton
Gene Ontology Cellular Component:
axolemma
cuticular plate
cytoplasm
cytosol
extracellular exosome
M band
neuronal postsynaptic density
nucleolus
spectrin
spectrin-associated cytoskeleton
Keywords:
3D-structure
Acetylation
Actin capping
Actin-binding
Alternative splicing
Calmodulin-binding
Cell membrane
Complete proteome
Cytoplasm
Cytoskeleton
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Interacts With:
Q9NRI5; P02549; Q13813

Publication

PubMed ID:
1527002 11665863 15815621 15489334 8406479 10806113 15262991 17081983 17924679 18088087 18691976 18669648 19413330 19369195 19690332 19608861 20068231 21269460 21406692 22223895 22814378 24117850 24275569 25944712 9164454 9817844