Names & Taxonomy
- Uniprot ID:
- Q01064
- Entry Name:
- PDE1B_HUMAN
- Status:
- reviewed
- Protein Names:
- Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Cam-PDE 1B) (EC 3.1.4.17) (63 kDa Cam-PDE)
- Gene Names:
- PDE1B PDE1B1 PDES1B
- Gene Names Primary:
- PDE1B
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 536
- Sequence:
- MELSPRSPPEMLEESDCPSPLELKSAPSKKMWIKLRSLLRYMVKQLENGEINIEELKKNLEYTASLLEAVYIDETRQILDTEDELQELRSDAVPSEVRDWLASTFTQQARAKGRRAEEKPKFRSIVHAVQAGIFVERMFRRTYTSVGPTYSTAVLNCLKNLDLWCFDVFSLNQAADDHALRTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQTKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTALQQLERIDKPKALSLLLHAADISHPTKQWLVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQPLADEDSKSKNQPSFQWRQPSLDVEVGDPNPDVVSFRSTWVKRIQENKQKWKERAASGITNQMSIDELSPCEEEAPPSPAEDEHNQNGNLD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate.
- Catalytic Activity:
- Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.
- Cofactor:
- COFACTOR: Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
- Enzyme Regulation:
- ENZYME REGULATION: Type I PDE are activated by the binding of calmodulin in the presence of Ca(2+).
- Active Site:
- ACT_SITE 223 223 Proton donor.
- Cross Reference Drug Bank:
- DB01244 DB00201 DB01023 DB00622
- Gene Ontology Go:
- cytosol
neuronal cell body
3',5'-cyclic-AMP phosphodiesterase activity
calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity
calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
metal ion binding
activation of phospholipase C activity
apoptotic process
blood coagulation
cAMP catabolic process
cellular response to granulocyte macrophage colony-stimulating factor stimulus
cellular response to macrophage colony-stimulating factor stimulus
cGMP catabolic process
epidermal growth factor receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
locomotory behavior
monocyte differentiation
neurotrophin TRK receptor signaling pathway
regulation of dopamine metabolic process
regulation of neurotransmitter levels
response to amphetamine
serotonin metabolic process
signal transduction
visual learning - Gene Ontology Biological Process:
- activation of phospholipase C activity
apoptotic process
blood coagulation
cAMP catabolic process
cellular response to granulocyte macrophage colony-stimulating factor stimulus
cellular response to macrophage colony-stimulating factor stimulus
cGMP catabolic process
epidermal growth factor receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
locomotory behavior
monocyte differentiation
neurotrophin TRK receptor signaling pathway
regulation of dopamine metabolic process
regulation of neurotransmitter levels
response to amphetamine
serotonin metabolic process
signal transduction
visual learning - Gene Ontology Molecular Function:
- 3',5'-cyclic-AMP phosphodiesterase activity
calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity
calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
metal ion binding - Gene Ontology Cellular Component:
- cytosol
neuronal cell body - Keywords:
- 3D-structure
Alternative splicing
Calmodulin-binding
Complete proteome
Cytoplasm
Hydrolase
Metal-binding
Phosphoprotein
Reference proteome
cAMP
cGMP - Interacts With:
- Q9NUX5