Names & Taxonomy

Uniprot ID:
Q01064
Entry Name:
PDE1B_HUMAN
Status:
reviewed
Protein Names:
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Cam-PDE 1B) (EC 3.1.4.17) (63 kDa Cam-PDE)
Gene Names:
PDE1B PDE1B1 PDES1B
Gene Names Primary:
PDE1B
Organism:
Homo sapiens (Human)

Structure

Length:
536
Sequence:
MELSPRSPPEMLEESDCPSPLELKSAPSKKMWIKLRSLLRYMVKQLENGEINIEELKKNLEYTASLLEAVYIDETRQILDTEDELQELRSDAVPSEVRDWLASTFTQQARAKGRRAEEKPKFRSIVHAVQAGIFVERMFRRTYTSVGPTYSTAVLNCLKNLDLWCFDVFSLNQAADDHALRTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQTKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTALQQLERIDKPKALSLLLHAADISHPTKQWLVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQPLADEDSKSKNQPSFQWRQPSLDVEVGDPNPDVVSFRSTWVKRIQENKQKWKERAASGITNQMSIDELSPCEEEAPPSPAEDEHNQNGNLD
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm.

Function

Function:
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate.
Catalytic Activity:
Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.
Cofactor:
COFACTOR: Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
Enzyme Regulation:
ENZYME REGULATION: Type I PDE are activated by the binding of calmodulin in the presence of Ca(2+).
Active Site:
ACT_SITE 223 223 Proton donor.
Cross Reference Drug Bank:
DB01244 DB00201 DB01023 DB00622
Gene Ontology Go:
cytosol
neuronal cell body
3',5'-cyclic-AMP phosphodiesterase activity
calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity
calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
metal ion binding
activation of phospholipase C activity
apoptotic process
blood coagulation
cAMP catabolic process
cellular response to granulocyte macrophage colony-stimulating factor stimulus
cellular response to macrophage colony-stimulating factor stimulus
cGMP catabolic process
epidermal growth factor receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
locomotory behavior
monocyte differentiation
neurotrophin TRK receptor signaling pathway
regulation of dopamine metabolic process
regulation of neurotransmitter levels
response to amphetamine
serotonin metabolic process
signal transduction
visual learning
Gene Ontology Biological Process:
activation of phospholipase C activity
apoptotic process
blood coagulation
cAMP catabolic process
cellular response to granulocyte macrophage colony-stimulating factor stimulus
cellular response to macrophage colony-stimulating factor stimulus
cGMP catabolic process
epidermal growth factor receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
locomotory behavior
monocyte differentiation
neurotrophin TRK receptor signaling pathway
regulation of dopamine metabolic process
regulation of neurotransmitter levels
response to amphetamine
serotonin metabolic process
signal transduction
visual learning
Gene Ontology Molecular Function:
3',5'-cyclic-AMP phosphodiesterase activity
calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity
calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
metal ion binding
Gene Ontology Cellular Component:
cytosol
neuronal cell body
Keywords:
3D-structure
Alternative splicing
Calmodulin-binding
Complete proteome
Cytoplasm
Hydrolase
Metal-binding
Phosphoprotein
Reference proteome
cAMP
cGMP
Interacts With:
Q9NUX5

Publication

PubMed ID:
8855339 9419816 11747989 14702039 15489334 1326532 15260978