Names & Taxonomy
- Uniprot ID:
- Q00266
- Entry Name:
- METK1_HUMAN
- Status:
- reviewed
- Protein Names:
- S-adenosylmethionine synthase isoform type-1 (AdoMet synthase 1) (EC 2.5.1.6) (Methionine adenosyltransferase 1) (MAT 1) (Methionine adenosyltransferase I/III) (MAT-I/III)
- Gene Names:
- MAT1A AMS1 MATA1
- Gene Names Primary:
- MAT1A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 395
- Sequence:
- MNGPVDGLCDHSLSEGVFMFTSESVGEGHPDKICDQISDAVLDAHLKQDPNAKVACETVCKTGMVLLCGEITSMAMVDYQRVVRDTIKHIGYDDSAKGFDFKTCNVLVALEQQSPDIAQCVHLDRNEEDVGAGDQGLMFGYATDETEECMPLTIILAHKLNARMADLRRSGLLPWLRPDSKTQVTVQYMQDNGAVIPVRIHTIVISVQHNEDITLEEMRRALKEQVIRAVVPAKYLDEDTVYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLCRRVLVQVSYAIGVAEPLSISIFTYGTSQKTERELLDVVHKNFDLRPGVIVRDLDLKKPIYQKTACYGHFGRSEFPWEVPRKLVF
- Proteomes:
- UP000005640
Function
- Function:
- Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
- Pathway:
- Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.
- Catalytic Activity:
- ATP + L-methionine + H(2)O = phosphate + diphosphate + S-adenosyl-L-methionine.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Cross Reference Drug Bank:
- DB00134 DB00118
- Gene Ontology Go:
- cytosol
ATP binding
metal ion binding
methionine adenosyltransferase activity
cellular amino acid metabolic process
cellular nitrogen compound metabolic process
methylation
one-carbon metabolic process
S-adenosylmethionine biosynthetic process
selenium compound metabolic process
small molecule metabolic process
sulfur amino acid metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- cellular amino acid metabolic process
cellular nitrogen compound metabolic process
methylation
one-carbon metabolic process
S-adenosylmethionine biosynthetic process
selenium compound metabolic process
small molecule metabolic process
sulfur amino acid metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- ATP binding
metal ion binding
methionine adenosyltransferase activity - Gene Ontology Cellular Component:
- cytosol
- Keywords:
- 3D-structure
ATP-binding
Cobalt
Complete proteome
Disease mutation
Disulfide bond
Magnesium
Metal-binding
Nucleotide-binding
One-carbon metabolism
Polymorphism
Potassium
Reference proteome
S-nitrosylation
Transferase