Names & Taxonomy

Uniprot ID:
Q00266
Entry Name:
METK1_HUMAN
Status:
reviewed
Protein Names:
S-adenosylmethionine synthase isoform type-1 (AdoMet synthase 1) (EC 2.5.1.6) (Methionine adenosyltransferase 1) (MAT 1) (Methionine adenosyltransferase I/III) (MAT-I/III)
Gene Names:
MAT1A AMS1 MATA1
Gene Names Primary:
MAT1A
Organism:
Homo sapiens (Human)

Structure

Length:
395
Sequence:
MNGPVDGLCDHSLSEGVFMFTSESVGEGHPDKICDQISDAVLDAHLKQDPNAKVACETVCKTGMVLLCGEITSMAMVDYQRVVRDTIKHIGYDDSAKGFDFKTCNVLVALEQQSPDIAQCVHLDRNEEDVGAGDQGLMFGYATDETEECMPLTIILAHKLNARMADLRRSGLLPWLRPDSKTQVTVQYMQDNGAVIPVRIHTIVISVQHNEDITLEEMRRALKEQVIRAVVPAKYLDEDTVYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLCRRVLVQVSYAIGVAEPLSISIFTYGTSQKTERELLDVVHKNFDLRPGVIVRDLDLKKPIYQKTACYGHFGRSEFPWEVPRKLVF
Proteomes:
UP000005640

Function

Function:
Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
Pathway:
Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.
Catalytic Activity:
ATP + L-methionine + H(2)O = phosphate + diphosphate + S-adenosyl-L-methionine.
Cofactor:
COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Cross Reference Drug Bank:
DB00134 DB00118
Gene Ontology Go:
cytosol
ATP binding
metal ion binding
methionine adenosyltransferase activity
cellular amino acid metabolic process
cellular nitrogen compound metabolic process
methylation
one-carbon metabolic process
S-adenosylmethionine biosynthetic process
selenium compound metabolic process
small molecule metabolic process
sulfur amino acid metabolic process
xenobiotic metabolic process
Gene Ontology Biological Process:
cellular amino acid metabolic process
cellular nitrogen compound metabolic process
methylation
one-carbon metabolic process
S-adenosylmethionine biosynthetic process
selenium compound metabolic process
small molecule metabolic process
sulfur amino acid metabolic process
xenobiotic metabolic process
Gene Ontology Molecular Function:
ATP binding
metal ion binding
methionine adenosyltransferase activity
Gene Ontology Cellular Component:
cytosol
Keywords:
3D-structure
ATP-binding
Cobalt
Complete proteome
Disease mutation
Disulfide bond
Magnesium
Metal-binding
Nucleotide-binding
One-carbon metabolism
Polymorphism
Potassium
Reference proteome
S-nitrosylation
Transferase

Publication

PubMed ID:
8393662 1772450 15164054 15489334 21269460 24275569 7560086 8770875 9042912 10677294