Names & Taxonomy
- Uniprot ID:
- P82251
- Entry Name:
- BAT1_HUMAN
- Status:
- reviewed
- Protein Names:
- b(0,+)-type amino acid transporter 1 (b(0,+)AT1) (Glycoprotein-associated amino acid transporter b0,+AT1) (Solute carrier family 7 member 9)
- Gene Names:
- SLC7A9 BAT1
- Gene Names Primary:
- SLC7A9
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 487
- Sequence:
- MGDTGLRKRREDEKSIQSQEPKTTSLQKELGLISGISIIVGTIIGSGIFVSPKSVLSNTEAVGPCLIIWAACGVLATLGALCFAELGTMITKSGGEYPYLMEAYGPIPAYLFSWASLIVIKPTSFAIICLSFSEYVCAPFYVGCKPPQIVVKCLAAAAILFISTVNSLSVRLGSYVQNIFTAAKLVIVAIIIISGLVLLAQGNTKNFDNSFEGAQLSVGAISLAFYNGLWAYDGWNQLNYITEELRNPYRNLPLAIIIGIPLVTACYILMNVSYFTVMTATELLQSQAVAVTFGDRVLYPASWIVPLFVAFSTIGAANGTCFTAGRLIYVAGREGHMLKVLSYISVRRLTPAPAIIFYGIIATIYIIPGDINSLVNYFSFAAWLFYGLTILGLIVMRFTRKELERPIKVPVVIPVLMTLISVFLVLAPIISKPTWEYLYCVLFILSGLLFYFLFVHYKFGWAQKISKPITMHLQMLMEVVPPEEDPE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Apical cell membrane
Function
- Function:
- Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system b(0,+)-like activity). Thought to be responsible for the high-affinity reabsorption of cystine in the kidney tubule.
- Cross Reference Drug Bank:
- DB00138
- Gene Ontology Go:
- apical plasma membrane
brush border membrane
integral component of plasma membrane
plasma membrane
antiporter activity
L-cystine transmembrane transporter activity
neutral amino acid transmembrane transporter activity
peptide antigen binding
amino acid transport
blood coagulation
ion transport
L-cystine transport
leukocyte migration
neutral amino acid transport
protein complex assembly
transmembrane transport - Gene Ontology Biological Process:
- amino acid transport
blood coagulation
ion transport
L-cystine transport
leukocyte migration
neutral amino acid transport
protein complex assembly
transmembrane transport - Gene Ontology Molecular Function:
- antiporter activity
L-cystine transmembrane transporter activity
neutral amino acid transmembrane transporter activity
peptide antigen binding - Gene Ontology Cellular Component:
- apical plasma membrane
brush border membrane
integral component of plasma membrane
plasma membrane - Keywords:
- Amino-acid transport
Cell membrane
Complete proteome
Cystinuria
Disease mutation
Disulfide bond
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport