Names & Taxonomy

Uniprot ID:
P82251
Entry Name:
BAT1_HUMAN
Status:
reviewed
Protein Names:
b(0,+)-type amino acid transporter 1 (b(0,+)AT1) (Glycoprotein-associated amino acid transporter b0,+AT1) (Solute carrier family 7 member 9)
Gene Names:
SLC7A9 BAT1
Gene Names Primary:
SLC7A9
Organism:
Homo sapiens (Human)

Structure

Length:
487
Sequence:
MGDTGLRKRREDEKSIQSQEPKTTSLQKELGLISGISIIVGTIIGSGIFVSPKSVLSNTEAVGPCLIIWAACGVLATLGALCFAELGTMITKSGGEYPYLMEAYGPIPAYLFSWASLIVIKPTSFAIICLSFSEYVCAPFYVGCKPPQIVVKCLAAAAILFISTVNSLSVRLGSYVQNIFTAAKLVIVAIIIISGLVLLAQGNTKNFDNSFEGAQLSVGAISLAFYNGLWAYDGWNQLNYITEELRNPYRNLPLAIIIGIPLVTACYILMNVSYFTVMTATELLQSQAVAVTFGDRVLYPASWIVPLFVAFSTIGAANGTCFTAGRLIYVAGREGHMLKVLSYISVRRLTPAPAIIFYGIIATIYIIPGDINSLVNYFSFAAWLFYGLTILGLIVMRFTRKELERPIKVPVVIPVLMTLISVFLVLAPIISKPTWEYLYCVLFILSGLLFYFLFVHYKFGWAQKISKPITMHLQMLMEVVPPEEDPE
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Apical cell membrane

Function

Function:
Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system b(0,+)-like activity). Thought to be responsible for the high-affinity reabsorption of cystine in the kidney tubule.
Cross Reference Drug Bank:
DB00138
Gene Ontology Go:
apical plasma membrane
brush border membrane
integral component of plasma membrane
plasma membrane
antiporter activity
L-cystine transmembrane transporter activity
neutral amino acid transmembrane transporter activity
peptide antigen binding
amino acid transport
blood coagulation
ion transport
L-cystine transport
leukocyte migration
neutral amino acid transport
protein complex assembly
transmembrane transport
Gene Ontology Biological Process:
amino acid transport
blood coagulation
ion transport
L-cystine transport
leukocyte migration
neutral amino acid transport
protein complex assembly
transmembrane transport
Gene Ontology Molecular Function:
antiporter activity
L-cystine transmembrane transporter activity
neutral amino acid transmembrane transporter activity
peptide antigen binding
Gene Ontology Cellular Component:
apical plasma membrane
brush border membrane
integral component of plasma membrane
plasma membrane
Keywords:
Amino-acid transport
Cell membrane
Complete proteome
Cystinuria
Disease mutation
Disulfide bond
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
10471498 10588648 11318953 12371955 14702039 15489334 12167606 11157794 12234283 12820697 16138908 15635077 16609684 18752446 19782624