Names & Taxonomy

Uniprot ID:
P80188
Entry Name:
NGAL_HUMAN
Status:
reviewed
Protein Names:
Neutrophil gelatinase-associated lipocalin (NGAL) (25 kDa alpha-2-microglobulin-related subunit of MMP-9) (Lipocalin-2) (Oncogene 24p3) (Siderocalin LCN2) (p25)
Gene Names:
LCN2 HNL NGAL
Gene Names Primary:
LCN2
Organism:
Homo sapiens (Human)

Structure

Length:
198
Sequence:
MPLGLLWLGLALLGALHAQAQDSTSDLIPAPPLSKVPLQQNFQDNQFQGKWYVVGLAGNAILREDKDPQKMYATIYELKEDKSYNVTSVLFRKKKCDYWIRTFVPGCQPGEFTLGNIKSYPGLTSYLVRVVSTNYNQHAMVFFKKVSQNREYFKITLYGRTKELTSELKENFIRFSKSLGLPENHIVFPVPIDQCIDG
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted

Function

Function:
Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.
Gene Ontology Go:
cell
extracellular exosome
extracellular region
extracellular space
iron ion binding
small molecule binding
transporter activity
apoptotic process
cellular iron ion homeostasis
innate immune response
ion transport
siderophore transport
transmembrane transport
Gene Ontology Biological Process:
apoptotic process
cellular iron ion homeostasis
innate immune response
ion transport
siderophore transport
transmembrane transport
Gene Ontology Molecular Function:
iron ion binding
small molecule binding
transporter activity
Gene Ontology Cellular Component:
cell
extracellular exosome
extracellular region
extracellular space
Keywords:
3D-structure
Alternative splicing
Apoptosis
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Immunity
Innate immunity
Ion transport
Iron
Iron transport
Pyrrolidone carboxylic acid
Reference proteome
Secreted
Signal
Transport

Publication

PubMed ID:
8060329 9339356 14702039 15164053 15489334 7835423 7683678 1281792 12453413 15084671 16335952 16740002 19229297 19159218 21269460 10684642 10339412 12453412