Names & Taxonomy

Uniprot ID:
P80108
Entry Name:
PHLD_HUMAN
Status:
reviewed
Protein Names:
Phosphatidylinositol-glycan-specific phospholipase D (PI-G PLD) (EC 3.1.4.50) (Glycoprotein phospholipase D) (Glycosyl-phosphatidylinositol-specific phospholipase D) (GPI-PLD) (GPI-specific phospholipase D)
Gene Names:
GPLD1 PIGPLD1
Gene Names Primary:
GPLD1
Organism:
Homo sapiens (Human)

Structure

Length:
840
Sequence:
MSAFRLWPGLLIMLGSLCHRGSPCGLSTHVEIGHRALEFLQLHNGRVNYRELLLEHQDAYQAGIVFPDCFYPSICKGGKFHDVSESTHWTPFLNASVHYIRENYPLPWEKDTEKLVAFLFGITSHMAADVSWHSLGLEQGFLRTMGAIDFHGSYSEAHSAGDFGGDVLSQFEFNFNYLARRWYVPVKDLLGIYEKLYGRKVITENVIVDCSHIQFLEMYGEMLAVSKLYPTYSTKSPFLVEQFQEYFLGGLDDMAFWSTNIYHLTSFMLENGTSDCNLPENPLFIACGGQQNHTQGSKMQKNDFHRNLTTSLTESVDRNINYTERGVFFSVNSWTPDSMSFIYKALERNIRTMFIGGSQLSQKHVSSPLASYFLSFPYARLGWAMTSADLNQDGHGDLVVGAPGYSRPGHIHIGRVYLIYGNDLGLPPVDLDLDKEAHRILEGFQPSGRFGSALAVLDFNVDGVPDLAVGAPSVGSEQLTYKGAVYVYFGSKQGGMSSSPNITISCQDIYCNLGWTLLAADVNGDSEPDLVIGSPFAPGGGKQKGIVAAFYSGPSLSDKEKLNVEAANWTVRGEEDFSWFGYSLHGVTVDNRTLLLVGSPTWKNASRLGHLLHIRDEKKSLGRVYGYFPPNGQSWFTISGDKAMGKLGTSLSSGHVLMNGTLKQVLLVGAPTYDDVSKVAFLTVTLHQGGATRMYALTSDAQPLLLSTFSGDRRFSRFGGVLHLSDLDDDGLDEIIMAAPLRIADVTSGLIGGEDGRVYVYNGKETTLGDMTGKCKSWITPCPEEKAQYVLISPEASSRFGSSLITVRSKAKNQVVIAAGRSSLGARLSGALHVYSLGSD
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted.

Function

Function:
This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane.
Catalytic Activity:
6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(2)O = 6-(alpha-D-glucosaminyl)-1D-myo-inositol + phosphatidate.
Gene Ontology Go:
cytoplasm
extracellular exosome
extracellular space
intracellular
intracellular membrane-bounded organelle
lysosomal membrane
proteinaceous extracellular matrix
glycosylphosphatidylinositol phospholipase D activity
phospholipase D activity
sodium channel regulator activity
cell migration involved in sprouting angiogenesis
cellular response to calcium ion
cellular response to cholesterol
cellular response to drug
cellular response to insulin stimulus
cellular response to pH
cellular response to triglyceride
chondrocyte differentiation
complement receptor mediated signaling pathway
GPI anchor release
hematopoietic stem cell migration
hematopoietic stem cell migration to bone marrow
insulin receptor signaling pathway
negative regulation of cell proliferation
negative regulation of triglyceride catabolic process
ossification
phosphatidylcholine metabolic process
positive regulation of alkaline phosphatase activity
positive regulation of apoptotic process
positive regulation of cytolysis
positive regulation of endothelial cell migration
positive regulation of glucose metabolic process
positive regulation of high-density lipoprotein particle clearance
positive regulation of insulin secretion involved in cellular response to glucose stimulus
positive regulation of membrane protein ectodomain proteolysis
positive regulation of secretion
positive regulation of triglyceride biosynthetic process
regulation of cellular response to insulin stimulus
response to glucose
transepithelial transport
Gene Ontology Biological Process:
cell migration involved in sprouting angiogenesis
cellular response to calcium ion
cellular response to cholesterol
cellular response to drug
cellular response to insulin stimulus
cellular response to pH
cellular response to triglyceride
chondrocyte differentiation
complement receptor mediated signaling pathway
GPI anchor release
hematopoietic stem cell migration
hematopoietic stem cell migration to bone marrow
insulin receptor signaling pathway
negative regulation of cell proliferation
negative regulation of triglyceride catabolic process
ossification
phosphatidylcholine metabolic process
positive regulation of alkaline phosphatase activity
positive regulation of apoptotic process
positive regulation of cytolysis
positive regulation of endothelial cell migration
positive regulation of glucose metabolic process
positive regulation of high-density lipoprotein particle clearance
positive regulation of insulin secretion involved in cellular response to glucose stimulus
positive regulation of membrane protein ectodomain proteolysis
positive regulation of secretion
positive regulation of triglyceride biosynthetic process
regulation of cellular response to insulin stimulus
response to glucose
transepithelial transport
Gene Ontology Molecular Function:
glycosylphosphatidylinositol phospholipase D activity
phospholipase D activity
sodium channel regulator activity
Gene Ontology Cellular Component:
cytoplasm
extracellular exosome
extracellular space
intracellular
intracellular membrane-bounded organelle
lysosomal membrane
proteinaceous extracellular matrix
Keywords:
Alternative splicing
Complete proteome
Direct protein sequencing
Glycoprotein
Hydrolase
Polymorphism
Reference proteome
Repeat
Secreted
Signal

Publication

PubMed ID:
11072085 14574404 15489334 1606959 16335952 19159218