Names & Taxonomy
- Uniprot ID:
- P80075
- Entry Name:
- CCL8_HUMAN
- Status:
- reviewed
- Protein Names:
- C-C motif chemokine 8 (HC14) (Monocyte chemoattractant protein 2) (Monocyte chemotactic protein 2) (MCP-2) (Small-inducible cytokine A8) [Cleaved into: MCP-2(6-76)]
- Gene Names:
- CCL8 MCP2 SCYA10 SCYA8
- Gene Names Primary:
- CCL8
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 99
- Sequence:
- MKVSAALLCLLLMAATFSPQGLAQPDSVSIPITCCFNVINRKIPIQRLESYTRITNIQCPKEAVIFKTKRGKEVCADPKERWVRDSMKHLDQIFQNLKP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted.
Function
- Function:
- Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8.
- Gene Ontology Go:
- cell
extracellular space
CCR chemokine receptor binding
chemokine activity
heparin binding
phospholipase activator activity
protein kinase activity
calcium ion transport
cell-cell signaling
cellular calcium ion homeostasis
cellular response to interferon-gamma
cellular response to interleukin-1
cellular response to tumor necrosis factor
chemokine-mediated signaling pathway
chemotaxis
exocytosis
G-protein coupled receptor signaling pathway
inflammatory response
lymphocyte chemotaxis
monocyte chemotaxis
negative regulation of leukocyte proliferation
neutrophil chemotaxis
positive regulation of ERK1 and ERK2 cascade
positive regulation of GTPase activity
positive regulation of inflammatory response
positive regulation of leukocyte migration
protein phosphorylation
response to virus
signal transduction - Gene Ontology Biological Process:
- calcium ion transport
cell-cell signaling
cellular calcium ion homeostasis
cellular response to interferon-gamma
cellular response to interleukin-1
cellular response to tumor necrosis factor
chemokine-mediated signaling pathway
chemotaxis
exocytosis
G-protein coupled receptor signaling pathway
inflammatory response
lymphocyte chemotaxis
monocyte chemotaxis
negative regulation of leukocyte proliferation
neutrophil chemotaxis
positive regulation of ERK1 and ERK2 cascade
positive regulation of GTPase activity
positive regulation of inflammatory response
positive regulation of leukocyte migration
protein phosphorylation
response to virus
signal transduction - Gene Ontology Molecular Function:
- CCR chemokine receptor binding
chemokine activity
heparin binding
phospholipase activator activity
protein kinase activity - Gene Ontology Cellular Component:
- cell
extracellular space - Keywords:
- 3D-structure
Chemotaxis
Complete proteome
Cytokine
Direct protein sequencing
Disulfide bond
Heparin-binding
Inflammatory response
Polymorphism
Pyrrolidone carboxylic acid
Reference proteome
Secreted
Signal