Names & Taxonomy
- Uniprot ID:
- P78371
- Entry Name:
- TCPB_HUMAN
- Status:
- reviewed
- Protein Names:
- T-complex protein 1 subunit beta (TCP-1-beta) (CCT-beta)
- Gene Names:
- CCT2 99D8.1 CCTB
- Gene Names Primary:
- CCT2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 535
- Sequence:
- MASLSLAPVNIFKAGADEERAETARLTSFIGAIAIGDLVKSTLGPKGMDKILLSSGRDASLMVTNDGATILKNIGVDNPAAKVLVDMSRVQDDEVGDGTTSVTVLAAELLREAESLIAKKIHPQTIIAGWREATKAAREALLSSAVDHGSDEVKFRQDLMNIAGTTLSSKLLTHHKDHFTKLAVEAVLRLKGSGNLEAIHIIKKLGGSLADSYLDEGFLLDKKIGVNQPKRIENAKILIANTGMDTDKIKIFGSRVRVDSTAKVAEIEHAEKEKMKEKVERILKHGINCFINRQLIYNYPEQLFGAAGVMAIEHADFAGVERLALVTGGEIASTFDHPELVKLGSCKLIEEVMIGEDKLIHFSGVALGEACTIVLRGATQQILDEAERSLHDALCVLAQTVKDSRTVYGGGCSEMLMAHAVTQLANRTPGKEAVAMESYAKALRMLPTIIADNAGYDSADLVAQLRAAHSEGNTTAGLDMREGTIGDMAILGITESFQVKRQVLLSAAEAAEVILRVDNIIKAAPRKRVPDHHPC
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.
- Gene Ontology Go:
- cell body
chaperonin-containing T-complex
cytoplasm
cytosol
extracellular exosome
microtubule
myelin sheath
zona pellucida receptor complex
ATP binding
protein binding involved in protein folding
ubiquitin protein ligase binding
unfolded protein binding
'de novo' posttranslational protein folding
binding of sperm to zona pellucida
cellular protein metabolic process
chaperone mediated protein folding independent of cofactor
chaperone-mediated protein complex assembly
positive regulation of establishment of protein localization to telomere
positive regulation of protein localization to Cajal body
positive regulation of telomerase activity
positive regulation of telomerase RNA localization to Cajal body
positive regulation of telomere maintenance via telomerase
protein folding
protein stabilization
scaRNA localization to Cajal body
toxin transport - Gene Ontology Biological Process:
- 'de novo' posttranslational protein folding
binding of sperm to zona pellucida
cellular protein metabolic process
chaperone-mediated protein complex assembly
chaperone mediated protein folding independent of cofactor
positive regulation of establishment of protein localization to telomere
positive regulation of protein localization to Cajal body
positive regulation of telomerase activity
positive regulation of telomerase RNA localization to Cajal body
positive regulation of telomere maintenance via telomerase
protein folding
protein stabilization
scaRNA localization to Cajal body
toxin transport - Gene Ontology Molecular Function:
- ATP binding
protein binding involved in protein folding
ubiquitin protein ligase binding
unfolded protein binding - Gene Ontology Cellular Component:
- cell body
chaperonin-containing T-complex
cytoplasm
cytosol
extracellular exosome
microtubule
myelin sheath
zona pellucida receptor complex - Keywords:
- ATP-binding
Acetylation
Alternative splicing
Chaperone
Complete proteome
Cytoplasm
Direct protein sequencing
Nucleotide-binding
Phosphoprotein
Reference proteome - Interacts With:
- Q8IWZ6; O60232