Names & Taxonomy

Uniprot ID:
P78368
Entry Name:
KC1G2_HUMAN
Status:
reviewed
Protein Names:
Casein kinase I isoform gamma-2 (CKI-gamma 2) (EC 2.7.11.1)
Gene Names:
CSNK1G2 CK1G2
Gene Names Primary:
CSNK1G2
Organism:
Homo sapiens (Human)

Structure

Length:
415
Sequence:
MDFDKKGGKGETEEGRRMSKAGGGRSSHGIRSSGTSSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLSATEGVPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRSGFVFDYEYDWAGKPLPTPIGTVHTDLPSQPQLRDKTQPHSKNQALNSTNGELNADDPTAGHSNAPITAPAEVEVADETKCCCFFKRRKRKSLQRHK
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm

Function

Function:
Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation.
Catalytic Activity:
ATP + a protein = ADP + a phosphoprotein.
Enzyme Regulation:
ENZYME REGULATION: Stimulated by estrogen. Repressed by 5-iodotubercidin (DB04604).
Active Site:
ACT_SITE 165 165 Proton acceptor.
Gene Ontology Go:
cytosol
membrane
ATP binding
magnesium ion binding
peptide binding
protein serine/threonine kinase activity
peptidyl-serine phosphorylation
positive regulation of canonical Wnt signaling pathway
protein autophosphorylation
protein phosphorylation
signal transduction
small molecule metabolic process
sphingolipid biosynthetic process
sphingolipid metabolic process
Wnt signaling pathway
Gene Ontology Biological Process:
peptidyl-serine phosphorylation
positive regulation of canonical Wnt signaling pathway
protein autophosphorylation
protein phosphorylation
signal transduction
small molecule metabolic process
sphingolipid biosynthetic process
sphingolipid metabolic process
Wnt signaling pathway
Gene Ontology Molecular Function:
ATP binding
magnesium ion binding
peptide binding
protein serine/threonine kinase activity
Gene Ontology Cellular Component:
cytosol
membrane
Keywords:
3D-structure
ATP-binding
Complete proteome
Cytoplasm
Kinase
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Serine/threonine-protein kinase
Transferase
Wnt signaling pathway
Interacts With:
Q92624; Q9Y5P4; P60409

Publication

PubMed ID:
9403068 19054851 15057824 15489334 15342122 15077195 15917222 18691976 18794808 19005213 19369195 19690332 17344846