Names & Taxonomy
- Uniprot ID:
- P78368
- Entry Name:
- KC1G2_HUMAN
- Status:
- reviewed
- Protein Names:
- Casein kinase I isoform gamma-2 (CKI-gamma 2) (EC 2.7.11.1)
- Gene Names:
- CSNK1G2 CK1G2
- Gene Names Primary:
- CSNK1G2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 415
- Sequence:
- MDFDKKGGKGETEEGRRMSKAGGGRSSHGIRSSGTSSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLSATEGVPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRSGFVFDYEYDWAGKPLPTPIGTVHTDLPSQPQLRDKTQPHSKNQALNSTNGELNADDPTAGHSNAPITAPAEVEVADETKCCCFFKRRKRKSLQRHK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation.
- Catalytic Activity:
- ATP + a protein = ADP + a phosphoprotein.
- Enzyme Regulation:
- ENZYME REGULATION: Stimulated by estrogen. Repressed by 5-iodotubercidin (DB04604).
- Active Site:
- ACT_SITE 165 165 Proton acceptor.
- Gene Ontology Go:
- cytosol
membrane
ATP binding
magnesium ion binding
peptide binding
protein serine/threonine kinase activity
peptidyl-serine phosphorylation
positive regulation of canonical Wnt signaling pathway
protein autophosphorylation
protein phosphorylation
signal transduction
small molecule metabolic process
sphingolipid biosynthetic process
sphingolipid metabolic process
Wnt signaling pathway - Gene Ontology Biological Process:
- peptidyl-serine phosphorylation
positive regulation of canonical Wnt signaling pathway
protein autophosphorylation
protein phosphorylation
signal transduction
small molecule metabolic process
sphingolipid biosynthetic process
sphingolipid metabolic process
Wnt signaling pathway - Gene Ontology Molecular Function:
- ATP binding
magnesium ion binding
peptide binding
protein serine/threonine kinase activity - Gene Ontology Cellular Component:
- cytosol
membrane - Keywords:
- 3D-structure
ATP-binding
Complete proteome
Cytoplasm
Kinase
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Serine/threonine-protein kinase
Transferase
Wnt signaling pathway - Interacts With:
- Q92624; Q9Y5P4; P60409