Names & Taxonomy

Uniprot ID:
P78352
Entry Name:
DLG4_HUMAN
Status:
reviewed
Protein Names:
Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)
Gene Names:
DLG4 PSD95
Gene Names Primary:
DLG4
Organism:
Homo sapiens (Human)

Structure

Length:
724
Sequence:
MDCLCIVTTKKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYELQVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERREWSRLKAKDWGSSSGSQGREDSVLSYETVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPARERL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity).
Cross Reference Drug Bank:
DB00536
Gene Ontology Go:
AMPA glutamate receptor complex
basolateral plasma membrane
cell junction
cerebellar mossy fiber
cortical cytoskeleton
cytoplasm
dendrite cytoplasm
dendritic spine
endocytic vesicle membrane
endoplasmic reticulum
excitatory synapse
extrinsic component of cytoplasmic side of plasma membrane
juxtaparanode region of axon
neuron projection terminus
neuron spine
neuronal postsynaptic density
plasma membrane
postsynaptic density
postsynaptic membrane
synapse
synaptic vesicle
acetylcholine receptor binding
beta-1 adrenergic receptor binding
D1 dopamine receptor binding
guanylate kinase activity
ionotropic glutamate receptor binding
kinase binding
neuroligin family protein binding
P2Y1 nucleotide receptor binding
PDZ domain binding
protein C-terminus binding
protein complex binding
protein phosphatase binding
scaffold protein binding
activation of MAPKK activity
AMPA glutamate receptor clustering
axon guidance
dendritic spine morphogenesis
epidermal growth factor receptor signaling pathway
establishment of protein localization
establishment or maintenance of epithelial cell apical/basal polarity
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
GDP metabolic process
GMP metabolic process
innate immune response
insulin receptor signaling pathway
learning
locomotory exploration behavior
MAPK cascade
negative regulation of receptor internalization
nervous system development
neuromuscular process controlling balance
neurotrophin TRK receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
positive regulation of excitatory postsynaptic potential
positive regulation of synaptic transmission
protein complex assembly
protein localization to synapse
Ras protein signal transduction
receptor localization to synapse
regulation of grooming behavior
regulation of long-term neuronal synaptic plasticity
regulation of N-methyl-D-aspartate selective glutamate receptor activity
signal transduction
small GTPase mediated signal transduction
social behavior
synaptic transmission
synaptic vesicle maturation
vascular endothelial growth factor receptor signaling pathway
vocalization behavior
Gene Ontology Biological Process:
activation of MAPKK activity
AMPA glutamate receptor clustering
axon guidance
dendritic spine morphogenesis
epidermal growth factor receptor signaling pathway
establishment of protein localization
establishment or maintenance of epithelial cell apical/basal polarity
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
GDP metabolic process
GMP metabolic process
innate immune response
insulin receptor signaling pathway
learning
locomotory exploration behavior
MAPK cascade
negative regulation of receptor internalization
nervous system development
neuromuscular process controlling balance
neurotrophin TRK receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
positive regulation of excitatory postsynaptic potential
positive regulation of synaptic transmission
protein complex assembly
protein localization to synapse
Ras protein signal transduction
receptor localization to synapse
regulation of grooming behavior
regulation of long-term neuronal synaptic plasticity
regulation of N-methyl-D-aspartate selective glutamate receptor activity
signal transduction
small GTPase mediated signal transduction
social behavior
synaptic transmission
synaptic vesicle maturation
vascular endothelial growth factor receptor signaling pathway
vocalization behavior
Gene Ontology Molecular Function:
acetylcholine receptor binding
beta-1 adrenergic receptor binding
D1 dopamine receptor binding
guanylate kinase activity
ionotropic glutamate receptor binding
kinase binding
neuroligin family protein binding
P2Y1 nucleotide receptor binding
PDZ domain binding
protein complex binding
protein C-terminus binding
protein phosphatase binding
scaffold protein binding
Gene Ontology Cellular Component:
AMPA glutamate receptor complex
basolateral plasma membrane
cell junction
cerebellar mossy fiber
cortical cytoskeleton
cytoplasm
dendrite cytoplasm
dendritic spine
endocytic vesicle membrane
endoplasmic reticulum
excitatory synapse
extrinsic component of cytoplasmic side of plasma membrane
juxtaparanode region of axon
neuronal postsynaptic density
neuron projection terminus
neuron spine
plasma membrane
postsynaptic density
postsynaptic membrane
synapse
synaptic vesicle
Keywords:
3D-structure
Alternative splicing
Cell junction
Cell membrane
Cell projection
Complete proteome
Lipoprotein
Membrane
Palmitate
Phosphoprotein
Postsynaptic cell membrane
Reference proteome
Repeat
SH3 domain
Synapse
Interacts With:
Q9P021; O14490; P97836-5; Q15303; Q8VDU0; Q12879; Q13224; Q14957; Q09470; P10499; P63142; P15384; P22459; P15385; O60333-3; Q00987

Publication

PubMed ID:
9286702 10582582 14702039 16625196 7477295 9278515 10859302 10725395 12151521 16630835 19118189 25780553 11744724