Names & Taxonomy
- Uniprot ID:
- P78348
- Entry Name:
- ASIC1_HUMAN
- Status:
- reviewed
- Protein Names:
- Acid-sensing ion channel 1 (ASIC1) (Amiloride-sensitive cation channel 2, neuronal) (Brain sodium channel 2) (BNaC2)
- Gene Names:
- ASIC1 ACCN2 BNAC2
- Gene Names Primary:
- ASIC1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 528
- Sequence:
- MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCVCTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNNRYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEVCSAEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARGTFEDFTC
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Isoform 2 and isoform 3 function as proton-gated sodium channels; they are activated by a drop of the extracellular pH and then become rapidly desensitized. The channel generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Isoform 2 can also transport potassium, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 can also transport calcium ions. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear.
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by the diuretic amiloride. Inhibited by Cs(1+) ions. Inhibited by spider venom psalmotoxin 1; this locks the channel into its desensitized conformation.
- Cross Reference Drug Bank:
- DB00594 DB00586
- Gene Ontology Go:
- cell surface
integral component of plasma membrane
plasma membrane
synapse
acid-sensing ion channel activity
ion gated channel activity
ligand-gated sodium channel activity
associative learning
calcium ion transmembrane transport
cellular response to pH
ion transmembrane transport
memory
negative regulation of neurotransmitter secretion
protein homotrimerization
regulation of membrane potential
response to acidic pH
response to pH
sensory perception of sour taste
signal transduction
sodium ion transmembrane transport
sodium ion transport
transmembrane transport
transport - Gene Ontology Biological Process:
- associative learning
calcium ion transmembrane transport
cellular response to pH
ion transmembrane transport
memory
negative regulation of neurotransmitter secretion
protein homotrimerization
regulation of membrane potential
response to acidic pH
response to pH
sensory perception of sour taste
signal transduction
sodium ion transmembrane transport
sodium ion transport
transmembrane transport
transport - Gene Ontology Molecular Function:
- acid-sensing ion channel activity
ion gated channel activity
ligand-gated sodium channel activity - Gene Ontology Cellular Component:
- cell surface
integral component of plasma membrane
plasma membrane
synapse - Keywords:
- Alternative splicing
Calcium
Calcium transport
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Ion channel
Ion transport
Membrane
Phosphoprotein
Reference proteome
Sodium
Sodium channel
Sodium transport
Transmembrane
Transmembrane helix
Transport - Interacts With:
- Q9NRD5