Names & Taxonomy
- Uniprot ID:
- P78330
- Entry Name:
- SERB_HUMAN
- Status:
- reviewed
- Protein Names:
- Phosphoserine phosphatase (PSP) (PSPase) (EC 3.1.3.3) (L-3-phosphoserine phosphatase) (O-phosphoserine phosphohydrolase)
- Gene Names:
- PSPH
- Gene Names Primary:
- PSPH
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 225
- Sequence:
- MVSHSELRKLFYSADAVCFDVDSTVIREEGIDELAKICGVEDAVSEMTRRAMGGAVPFKAALTERLALIQPSREQVQRLIAEQPPHLTPGIRELVSRLQERNVQVFLISGGFRSIVEHVASKLNIPATNVFANRLKFYFNGEYAGFDETQPTAESGGKGKVIKLLKEKFHFKKIIMIGDGATDMEACPPADAFIGFGGNVIRQQVKDNAKWYITDFVELLGELEE
- Proteomes:
- UP000005640
Function
- Function:
- Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates.
- Pathway:
- Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.
- Catalytic Activity:
- O-phospho-L(or D)-serine + H(2)O = L(or D)-serine + phosphate.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by calcium ions.
- Active Site:
- ACT_SITE 20 20 Nucleophile.; ACT_SITE 22 22 Proton donor.
- Gene Ontology Go:
- cytoplasm
cytosol
neuron projection
calcium ion binding
magnesium ion binding
phosphoserine phosphatase activity
protein homodimerization activity
cellular amino acid biosynthetic process
cellular nitrogen compound metabolic process
dephosphorylation
L-serine biosynthetic process
L-serine metabolic process
response to mechanical stimulus
response to nutrient levels
response to testosterone
small molecule metabolic process - Gene Ontology Biological Process:
- cellular amino acid biosynthetic process
cellular nitrogen compound metabolic process
dephosphorylation
L-serine biosynthetic process
L-serine metabolic process
response to mechanical stimulus
response to nutrient levels
response to testosterone
small molecule metabolic process - Gene Ontology Molecular Function:
- calcium ion binding
magnesium ion binding
phosphoserine phosphatase activity
protein homodimerization activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
neuron projection - Keywords:
- 3D-structure
Acetylation
Amino-acid biosynthesis
Complete proteome
Disease mutation
Hydrolase
Magnesium
Metal-binding
Reference proteome
Serine biosynthesis - Interacts With:
- Q9NVP2; Q14558; Q9Y6J8