Names & Taxonomy
- Uniprot ID:
- P68871
- Entry Name:
- HBB_HUMAN
- Status:
- reviewed
- Protein Names:
- Hemoglobin subunit beta (Beta-globin) (Hemoglobin beta chain) [Cleaved into: LVV-hemorphin-7; Spinorphin]
- Gene Names:
- HBB
- Gene Names Primary:
- HBB
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 147
- Sequence:
- MVHLTPEEKSAVTALWGKVNVDEVGGEALGRLLVVYPWTQRFFESFGDLSTPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLKGTFATLSELHCDKLHVDPENFRLLGNVLVCVLAHHFGKEFTPPVQAAYQKVVAGVANALAHKYH
- Proteomes:
- UP000005640
Function
- Function:
- Involved in oxygen transport from the lung to the various peripheral tissues.; LVV-hemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure.; Spinorphin: functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation.
- Cross Reference Drug Bank:
- DB00893
- Gene Ontology Go:
- blood microparticle
cytosol
endocytic vesicle lumen
extracellular exosome
extracellular region
haptoglobin-hemoglobin complex
hemoglobin complex
heme binding
hemoglobin binding
iron ion binding
oxygen binding
oxygen transporter activity
bicarbonate transport
blood coagulation
cellular oxidant detoxification
hydrogen peroxide catabolic process
nitric oxide transport
oxygen transport
platelet aggregation
positive regulation of cell death
positive regulation of nitric oxide biosynthetic process
protein heterooligomerization
receptor-mediated endocytosis
regulation of blood pressure
regulation of blood vessel size
renal absorption
response to hydrogen peroxide
small molecule metabolic process - Gene Ontology Biological Process:
- bicarbonate transport
blood coagulation
cellular oxidant detoxification
hydrogen peroxide catabolic process
nitric oxide transport
oxygen transport
platelet aggregation
positive regulation of cell death
positive regulation of nitric oxide biosynthetic process
protein heterooligomerization
receptor-mediated endocytosis
regulation of blood pressure
regulation of blood vessel size
renal absorption
response to hydrogen peroxide
small molecule metabolic process - Gene Ontology Molecular Function:
- heme binding
hemoglobin binding
iron ion binding
oxygen binding
oxygen transporter activity - Gene Ontology Cellular Component:
- blood microparticle
cytosol
endocytic vesicle lumen
extracellular exosome
extracellular region
haptoglobin-hemoglobin complex
hemoglobin complex - Keywords:
- 3D-structure
Acetylation
Complete proteome
Congenital dyserythropoietic anemia
Direct protein sequencing
Disease mutation
Glycation
Glycoprotein
Heme
Hereditary hemolytic anemia
Hypotensive agent
Iron
Metal-binding
Oxygen transport
Phosphoprotein
Polymorphism
Pyruvate
Reference proteome
S-nitrosylation
Transport
Vasoactive - Interacts With:
- P69905; P02008
Publication
- PubMed ID:
- 1019344 6254664 16175509 14702039 15489334 13872627 13464827 25946035 1575724 8401300 2581851 4555506 4531009 635569 7358733 6166632 6539334 3718478 1520632 8637569 9843411 10588683 11001883 11747442 12149194 12470213 16001361 16904236 17676725 21269460 24275569 4123689 1195378 1177322 7373648 6726807 1567857 1507231 8377203 8642597 9521756 9830011 12454462 24100324 5919752 1115799 186485 1971109 8330974 721609 4850241 3707969 3654265 8718692 3384710 6166590 6629823 1247583 1138922 992050 6434492 1814856 8641705 8602627 2399911 1511986 1301199 8111050 8811317 1917539 3666141 1487420 826083 3754244 2513289 8745430 8144352 429365 1787097 4639022 2101840 6618888 8330972 7173395 1634367 3744871 7693620 3557994 1540659 3384708 3691763 6629824 2384314 7338468 893142 1517102 2634671 3838976 8330979 3937824 891976 3623975 7161106 3384709 668922 8522332 6629822 9761252 3384707 6857757 4129558 6687721 13897827 6526653 4852224 1917537 7238856 2599880 1917530 7338469 6259091 2599881 2079435 8280608 8704193 10398311 11300351 11300344 11939514 12144064 12603091 12908805 15481886