Names & Taxonomy
- Uniprot ID:
- P68133
- Entry Name:
- ACTS_HUMAN
- Status:
- reviewed
- Protein Names:
- Actin, alpha skeletal muscle (Alpha-actin-1)
- Gene Names:
- ACTA1 ACTA
- Gene Names Primary:
- ACTA1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 377
- Sequence:
- MCDEDETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKCF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, cytoskeleton.
Function
- Function:
- Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
- Gene Ontology Go:
- actin cytoskeleton
actin filament
blood microparticle
cell body
cytosol
extracellular exosome
extracellular space
filopodium
lamellipodium
sarcomere
stress fiber
striated muscle thin filament
ADP binding
ATP binding
myosin binding
structural constituent of cytoskeleton
cell growth
mesenchyme migration
muscle contraction
muscle filament sliding
positive regulation of gene expression
response to extracellular stimulus
response to lithium ion
response to mechanical stimulus
response to steroid hormone
skeletal muscle fiber adaptation
skeletal muscle fiber development
skeletal muscle thin filament assembly - Gene Ontology Biological Process:
- cell growth
mesenchyme migration
muscle contraction
muscle filament sliding
positive regulation of gene expression
response to extracellular stimulus
response to lithium ion
response to mechanical stimulus
response to steroid hormone
skeletal muscle fiber adaptation
skeletal muscle fiber development
skeletal muscle thin filament assembly - Gene Ontology Molecular Function:
- ADP binding
ATP binding
myosin binding
structural constituent of cytoskeleton - Gene Ontology Cellular Component:
- actin cytoskeleton
actin filament
blood microparticle
cell body
cytosol
extracellular exosome
extracellular space
filopodium
lamellipodium
sarcomere
stress fiber
striated muscle thin filament - Keywords:
- 3D-structure
ATP-binding
Acetylation
Complete proteome
Cytoplasm
Cytoskeleton
Disease mutation
Isopeptide bond
Methylation
Muscle protein
Nemaline myopathy
Nucleotide-binding
Oxidation
Reference proteome