Names & Taxonomy
- Uniprot ID:
- P67775
- Entry Name:
- PP2AA_HUMAN
- Status:
- reviewed
- Protein Names:
- Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16) (Replication protein C) (RP-C)
- Gene Names:
- PPP2CA
- Gene Names Primary:
- PPP2CA
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 309
- Sequence:
- MDEKVFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHVTRRTPDYFL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'.
- Catalytic Activity:
- -serine/threonine phosphate + H(2)O = -serine/threonine + phosphate.
- Cofactor:
- COFACTOR: Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
- Active Site:
- ACT_SITE 118 118 Proton donor.
- Cross Reference Drug Bank:
- DB00163
- Gene Ontology Go:
- chromosome, centromeric region
cytosol
extracellular exosome
membrane
microtubule cytoskeleton
mitochondrion
nucleus
plasma membrane
protein phosphatase type 2A complex
spindle pole
metal ion binding
phosphoprotein phosphatase activity
apoptotic process
ceramide metabolic process
fibroblast growth factor receptor signaling pathway
gene expression
inactivation of MAPK activity
meiotic cell cycle
mesoderm development
mitotic cell cycle
mitotic nuclear envelope reassembly
negative regulation of cell growth
negative regulation of epithelial to mesenchymal transition
negative regulation of tyrosine phosphorylation of Stat3 protein
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
positive regulation of protein serine/threonine kinase activity
protein dephosphorylation
regulation of cell adhesion
regulation of cell differentiation
regulation of DNA replication
regulation of growth
regulation of transcription, DNA-templated
regulation of Wnt signaling pathway
response to organic substance
RNA splicing
second-messenger-mediated signaling - Gene Ontology Biological Process:
- apoptotic process
ceramide metabolic process
fibroblast growth factor receptor signaling pathway
gene expression
inactivation of MAPK activity
meiotic cell cycle
mesoderm development
mitotic cell cycle
mitotic nuclear envelope reassembly
negative regulation of cell growth
negative regulation of epithelial to mesenchymal transition
negative regulation of tyrosine phosphorylation of Stat3 protein
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
positive regulation of protein serine/threonine kinase activity
protein dephosphorylation
regulation of cell adhesion
regulation of cell differentiation
regulation of DNA replication
regulation of growth
regulation of transcription, DNA-templated
regulation of Wnt signaling pathway
response to organic substance
RNA splicing
second-messenger-mediated signaling - Gene Ontology Molecular Function:
- metal ion binding
phosphoprotein phosphatase activity - Gene Ontology Cellular Component:
- chromosome, centromeric region
cytosol
extracellular exosome
membrane
microtubule cytoskeleton
mitochondrion
nucleus
plasma membrane
protein phosphatase type 2A complex
spindle pole - Keywords:
- 3D-structure
Alternative splicing
Centromere
Chromosome
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Hydrolase
Manganese
Meiosis
Metal-binding
Methylation
Nucleus
Phosphoprotein
Polymorphism
Protein phosphatase
Reference proteome
Ubl conjugation - Interacts With:
- P31749; P39687; P03129; P04020; P46695; P78318; Q61249; O14920; Q9Y6K9; Q969F8; P97346; P30153; P30154; Q9Y2T4; Q15172; Q15173; Q13362; P28749; Q08999; Q04206; O43815; O75663; Q15645