Names & Taxonomy
- Uniprot ID:
- P63098
- Entry Name:
- CANB1_HUMAN
- Status:
- reviewed
- Protein Names:
- Calcineurin subunit B type 1 (Protein phosphatase 2B regulatory subunit 1) (Protein phosphatase 3 regulatory subunit B alpha isoform 1)
- Gene Names:
- PPP3R1 CNA2 CNB
- Gene Names Primary:
- PPP3R1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 170
- Sequence:
- MGNEASYPLEMCSHFDADEIKRLGKRFKKLDLDNSGSLSVEEFMSLPELQQNPLVQRVIDIFDTDGNGEVDFKEFIEGVSQFSVKGDKEQKLRFAFRIYDMDKDGYISNGELFQVLKMMVGNNLKDTQLQQIVDKTIINADKDGDGRISFEEFCAVVGGLDIHKKMVVDV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, cytosol
Function
- Function:
- Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.
- Gene Ontology Go:
- calcineurin complex
cytosol
mitochondrion
nucleoplasm
sarcolemma
calcium ion binding
calcium-dependent protein serine/threonine phosphatase activity
calmodulin binding
protein domain specific binding
apoptotic process
calcineurin-NFAT signaling cascade
Fc-epsilon receptor signaling pathway
innate immune response
intrinsic apoptotic signaling pathway
positive regulation of NFAT protein import into nucleus
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
positive regulation of transcription from RNA polymerase II promoter
programmed cell death
protein dephosphorylation
stimulatory C-type lectin receptor signaling pathway - Gene Ontology Biological Process:
- apoptotic process
calcineurin-NFAT signaling cascade
Fc-epsilon receptor signaling pathway
innate immune response
intrinsic apoptotic signaling pathway
positive regulation of NFAT protein import into nucleus
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
positive regulation of transcription from RNA polymerase II promoter
programmed cell death
protein dephosphorylation
stimulatory C-type lectin receptor signaling pathway - Gene Ontology Molecular Function:
- calcium-dependent protein serine/threonine phosphatase activity
calcium ion binding
calmodulin binding
protein domain specific binding - Gene Ontology Cellular Component:
- calcineurin complex
cytosol
mitochondrion
nucleoplasm
sarcolemma - Keywords:
- 3D-structure
Calcium
Cell membrane
Complete proteome
Cytoplasm
Direct protein sequencing
Lipoprotein
Membrane
Metal-binding
Myristate
Phosphoprotein
Reference proteome
Repeat - Interacts With:
- Q99683; Q08209