Names & Taxonomy

Uniprot ID:
P63027
Entry Name:
VAMP2_HUMAN
Status:
reviewed
Protein Names:
Vesicle-associated membrane protein 2 (VAMP-2) (Synaptobrevin-2)
Gene Names:
VAMP2 SYB2
Gene Names Primary:
VAMP2
Organism:
Homo sapiens (Human)

Structure

Length:
116
Sequence:
MSATAATAPPAAPAGEGGPPAPPPNLTSNRRLQQTQAQVDEVVDIMRVNVDKVLERDQKLSELDDRADALQAGASQFETSAAKLKRKYWWKNLKMMIILGVICAIILIIIIVYFST
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane protein. Cell junction, synapse, synaptosome. Cell membrane

Function

Function:
Involved in the targeting and/or fusion of transport vesicles to their target membrane. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1.
Cross Reference Drug Bank:
DB00042
Gene Ontology Go:
cell junction
clathrin-coated vesicle
clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
clathrin-sculpted glutamate transport vesicle membrane
clathrin-sculpted monoamine transport vesicle membrane
cytoplasmic vesicle
cytosol
extracellular exosome
integral component of plasma membrane
intracellular membrane-bounded organelle
membrane
neuron projection
neuron projection terminus
perinuclear region of cytoplasm
plasma membrane
secretory granule
secretory granule membrane
SNARE complex
storage vacuole
synapse
synaptic vesicle
synaptic vesicle membrane
synaptobrevin 2-SNAP-25-syntaxin-1a complex
synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex
terminal bouton
trans-Golgi network
vesicle
voltage-gated potassium channel complex
zymogen granule membrane
calcium-dependent protein binding
calmodulin binding
phospholipid binding
protein self-association
SNAP receptor activity
SNARE binding
syntaxin binding
syntaxin-1 binding
calcium ion regulated exocytosis
cellular protein metabolic process
cellular response to insulin stimulus
energy reserve metabolic process
eosinophil degranulation
exocytosis
glutamate secretion
Golgi to plasma membrane protein transport
long-term synaptic potentiation
membrane fusion
membrane organization
neurotransmitter secretion
positive regulation of intracellular protein transport
post-Golgi vesicle-mediated transport
protein complex assembly
protein transport
regulation of delayed rectifier potassium channel activity
regulation of exocytosis
regulation of insulin secretion
regulation of vesicle-mediated transport
response to glucose
small molecule metabolic process
synaptic transmission
synaptic vesicle exocytosis
vesicle fusion
vesicle-mediated transport
Gene Ontology Biological Process:
calcium ion regulated exocytosis
cellular protein metabolic process
cellular response to insulin stimulus
energy reserve metabolic process
eosinophil degranulation
exocytosis
glutamate secretion
Golgi to plasma membrane protein transport
long-term synaptic potentiation
membrane fusion
membrane organization
neurotransmitter secretion
positive regulation of intracellular protein transport
post-Golgi vesicle-mediated transport
protein complex assembly
protein transport
regulation of delayed rectifier potassium channel activity
regulation of exocytosis
regulation of insulin secretion
regulation of vesicle-mediated transport
response to glucose
small molecule metabolic process
synaptic transmission
synaptic vesicle exocytosis
vesicle fusion
vesicle-mediated transport
Gene Ontology Molecular Function:
calcium-dependent protein binding
calmodulin binding
phospholipid binding
protein self-association
SNAP receptor activity
SNARE binding
syntaxin-1 binding
syntaxin binding
Gene Ontology Cellular Component:
cell junction
clathrin-coated vesicle
clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
clathrin-sculpted glutamate transport vesicle membrane
clathrin-sculpted monoamine transport vesicle membrane
cytoplasmic vesicle
cytosol
extracellular exosome
integral component of plasma membrane
intracellular membrane-bounded organelle
membrane
neuron projection
neuron projection terminus
perinuclear region of cytoplasm
plasma membrane
secretory granule
secretory granule membrane
SNARE complex
storage vacuole
synapse
synaptic vesicle
synaptic vesicle membrane
synaptobrevin 2-SNAP-25-syntaxin-1a complex
synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex
terminal bouton
trans-Golgi network
vesicle
voltage-gated potassium channel complex
zymogen granule membrane
Keywords:
3D-structure
Acetylation
Cell junction
Cell membrane
Coiled coil
Complete proteome
Cytoplasmic vesicle
Membrane
Phosphoprotein
Reference proteome
Synapse
Synaptosome
Transmembrane
Transmembrane helix
Interacts With:
D2KHQ9; A7GBG3; O55012; O94806; O95721; Q12846

Publication

PubMed ID:
1976629 14702039 15489334 8760387 7835332 17313651 10932255