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Names & Taxonomy

Uniprot ID:: P62993
Entry Name:: GRB2_HUMAN
Status:: reviewed
Protein Names:: Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene Names:: GRB2 ASH
Gene Names Primary:: GRB2
Organism:: Homo sapiens (Human)

Structure

Length:: 217
Sequence:: MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
Proteomes:: UP000005640

Subcellular location

Subcellular Location:: Nucleus

Function

Function:: Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.; Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.
Cross Reference Drug Bank:: DB00061
Gene Ontology Go:: cell-cell junction
COP9 signalosome
cytoplasm
cytosol
endosome
extracellular exosome
Golgi apparatus
Grb2-EGFR complex
nucleolus
nucleoplasm
nucleus
plasma membrane
vesicle membrane
ephrin receptor binding
epidermal growth factor receptor binding
identical protein binding
insulin receptor substrate binding
neurotrophin TRKA receptor binding
poly(A) RNA binding
protein kinase binding
SH3 domain binding
SH3/SH2 adaptor activity
activation of MAPKK activity
anatomical structure formation involved in morphogenesis
axon guidance
blood coagulation
branching involved in labyrinthine layer morphogenesis
cell-cell signaling
cellular response to ionizing radiation
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
fibroblast growth factor receptor signaling pathway
innate immune response
insulin receptor signaling pathway
leukocyte migration
MAPK cascade
negative regulation of epidermal growth factor receptor signaling pathway
neurotrophin TRK receptor signaling pathway
phosphatidylinositol-mediated signaling
platelet activation
positive regulation of actin filament polymerization
positive regulation of reactive oxygen species metabolic process
Ras protein signal transduction
receptor internalization
signal transduction in response to DNA damage
small GTPase mediated signal transduction
T cell costimulation
vascular endothelial growth factor receptor signaling pathway
viral process
Gene Ontology Biological Process:: activation of MAPKK activity
anatomical structure formation involved in morphogenesis
axon guidance
blood coagulation
branching involved in labyrinthine layer morphogenesis
cell-cell signaling
cellular response to ionizing radiation
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
fibroblast growth factor receptor signaling pathway
innate immune response
insulin receptor signaling pathway
leukocyte migration
MAPK cascade
negative regulation of epidermal growth factor receptor signaling pathway
neurotrophin TRK receptor signaling pathway
phosphatidylinositol-mediated signaling
platelet activation
positive regulation of actin filament polymerization
positive regulation of reactive oxygen species metabolic process
Ras protein signal transduction
receptor internalization
signal transduction in response to DNA damage
small GTPase mediated signal transduction
T cell costimulation
vascular endothelial growth factor receptor signaling pathway
viral process
Gene Ontology Molecular Function:: ephrin receptor binding
epidermal growth factor receptor binding
identical protein binding
insulin receptor substrate binding
neurotrophin TRKA receptor binding
poly(A) RNA binding
protein kinase binding
SH3/SH2 adaptor activity
SH3 domain binding
Gene Ontology Cellular Component:: cell-cell junction
COP9 signalosome
cytoplasm
cytosol
endosome
extracellular exosome
Golgi apparatus
Grb2-EGFR complex
nucleolus
nucleoplasm
nucleus
plasma membrane
vesicle membrane
Keywords:: 3D-structure
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Direct protein sequencing
Endosome
Golgi apparatus
Host-virus interaction
Nucleus
Phosphoprotein
Reference proteome
Repeat
SH2 domain
SH3 domain
Interacts With:: Itself; O92972; P26662; P27958; Q9P2A4; P42684; Q15027; Q13444; Q08117; Q15109; Q01484; Q9BRR9; Q12774; Q66PJ3-4; Q9ULH1; O43150; P30530; P11274; Q8WV28; O60885; Q6P1W5; P22681; Q13191; Q9Y5K6; P98082; P98078; P14868; Q16643; Q92841; O14490; Q9P1A6; Q9Y2H0; Q05193; P50570; Q14185; Q7L190; P00533; P54762; Q12929; P04626; P21860; Q9UJM3; B7ZLH0; O15360; P21802; P21333; O75369; Q14315; Q13480; Q9UQC2; Q9H706; P61978; Q6IBN1; Q8IX15-3; Q9UKT9; Q0VD86; P35570; Q07666; P10721; P05787; O43561; Q13094; P48357; P25791; Q8TE12; Q8TBB1; Q9BRK4; Q13163; Q92918; Q8IVH8; Q9Y4K4; Q9H204; P35579; Q8WX92; Q9GZT8; Q13177; Q9NPB6-2; O00750; P27986; O00459; P19174; O14939; Q5SXH7; Q96PV4; Q07869; Q08209; Q9Y478; P34152; P18031; Q06124; P35235; Q9Y2R2; Q9H3S7; P29350; P18433; O14522; P06400; Q04864; Q8NFH8-2; Q15427; Q9UPX8; Q9BYB0; P29353; P29353-1; Q8WXH5; Q07889; Q62245; Q07890; O43597; O43295; O95630; O15056; Q5BJH2-2; Q92973; O75674; Q13625-3; Q9ULW0; P14373; O60636; Q16851; P15498; Q9UKW4; P55072; O00401; Q9Y2W2; O43516; Q8TF74; O15156

Names & Taxonomy

Structure

Subcellular location

Function

Publication