Names & Taxonomy

Uniprot ID:
P62837
Entry Name:
UB2D2_HUMAN
Status:
reviewed
Protein Names:
Ubiquitin-conjugating enzyme E2 D2 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D2) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D2) (Ubiquitin carrier protein D2) (Ubiquitin-conjugating enzyme E2(17)KB 2) (Ubiquitin-conjugating enzyme E2-17 kDa 2) (Ubiquitin-protein ligase D2) (p53-regulated ubiquitin-conjugating enzyme 1)
Gene Names:
UBE2D2 PUBC1 UBC4 UBC5B UBCH4 UBCH5B
Gene Names Primary:
UBE2D2
Organism:
Homo sapiens (Human)

Structure

Length:
147
Sequence:
MALKRIHKELNDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISKVLLSICSLLCDPNPDDPLVPEIARIYKTDREKYNRIAREWTQKYAM
Proteomes:
UP000005640

Function

Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3.
Pathway:
Protein modification; protein ubiquitination.
Catalytic Activity:
S-ubiquitinyl--L-cysteine + -L-cysteine = -L-cysteine + S-ubiquitinyl--L-cysteine.
Active Site:
ACT_SITE 85 85 Glycyl thioester intermediate.
Gene Ontology Go:
cytosol
extracellular exosome
nucleoplasm
protein complex
ubiquitin ligase complex
ATP binding
ubiquitin conjugating enzyme activity
ubiquitin-protein transferase activity
cellular protein modification process
cellular response to hypoxia
Fc-epsilon receptor signaling pathway
innate immune response
MyD88-independent toll-like receptor signaling pathway
protein autoubiquitination
protein K48-linked ubiquitination
protein polyubiquitination
protein ubiquitination
regulation of transcription from RNA polymerase II promoter in response to hypoxia
stimulatory C-type lectin receptor signaling pathway
T cell receptor signaling pathway
toll-like receptor 3 signaling pathway
toll-like receptor 4 signaling pathway
toll-like receptor signaling pathway
TRIF-dependent toll-like receptor signaling pathway
ubiquitin-dependent protein catabolic process
Gene Ontology Biological Process:
cellular protein modification process
cellular response to hypoxia
Fc-epsilon receptor signaling pathway
innate immune response
MyD88-independent toll-like receptor signaling pathway
protein autoubiquitination
protein K48-linked ubiquitination
protein polyubiquitination
protein ubiquitination
regulation of transcription from RNA polymerase II promoter in response to hypoxia
stimulatory C-type lectin receptor signaling pathway
T cell receptor signaling pathway
toll-like receptor 3 signaling pathway
toll-like receptor 4 signaling pathway
toll-like receptor signaling pathway
TRIF-dependent toll-like receptor signaling pathway
ubiquitin-dependent protein catabolic process
Gene Ontology Molecular Function:
ATP binding
ubiquitin conjugating enzyme activity
ubiquitin-protein transferase activity
Gene Ontology Cellular Component:
cytosol
extracellular exosome
nucleoplasm
protein complex
ubiquitin ligase complex
Keywords:
3D-structure
ATP-binding
Alternative splicing
Complete proteome
Direct protein sequencing
Nucleotide-binding
Reference proteome
Transferase
Ubl conjugation pathway
Interacts With:
O15151; Q99PZ6; Q96FW1; Q9Y3C5; Q68DV7; Q99942; Q9Y4K3; P98170; Q8ND25

Publication

PubMed ID:
8530467 7724550 16112646 14702039 15372022 15489334 10329681 10918611 12036302 15280377 15001359 17588522 18042044 18703417 18359941 19854139 20403326 20061386 20525694 21269460 15522302 20152160