Names & Taxonomy
- Uniprot ID:
- P62837
- Entry Name:
- UB2D2_HUMAN
- Status:
- reviewed
- Protein Names:
- Ubiquitin-conjugating enzyme E2 D2 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D2) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D2) (Ubiquitin carrier protein D2) (Ubiquitin-conjugating enzyme E2(17)KB 2) (Ubiquitin-conjugating enzyme E2-17 kDa 2) (Ubiquitin-protein ligase D2) (p53-regulated ubiquitin-conjugating enzyme 1)
- Gene Names:
- UBE2D2 PUBC1 UBC4 UBC5B UBCH4 UBCH5B
- Gene Names Primary:
- UBE2D2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 147
- Sequence:
- MALKRIHKELNDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISKVLLSICSLLCDPNPDDPLVPEIARIYKTDREKYNRIAREWTQKYAM
- Proteomes:
- UP000005640
Function
- Function:
- Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3.
- Pathway:
- Protein modification; protein ubiquitination.
- Catalytic Activity:
- S-ubiquitinyl--L-cysteine + -L-cysteine = -L-cysteine + S-ubiquitinyl--L-cysteine.
- Active Site:
- ACT_SITE 85 85 Glycyl thioester intermediate.
- Gene Ontology Go:
- cytosol
extracellular exosome
nucleoplasm
protein complex
ubiquitin ligase complex
ATP binding
ubiquitin conjugating enzyme activity
ubiquitin-protein transferase activity
cellular protein modification process
cellular response to hypoxia
Fc-epsilon receptor signaling pathway
innate immune response
MyD88-independent toll-like receptor signaling pathway
protein autoubiquitination
protein K48-linked ubiquitination
protein polyubiquitination
protein ubiquitination
regulation of transcription from RNA polymerase II promoter in response to hypoxia
stimulatory C-type lectin receptor signaling pathway
T cell receptor signaling pathway
toll-like receptor 3 signaling pathway
toll-like receptor 4 signaling pathway
toll-like receptor signaling pathway
TRIF-dependent toll-like receptor signaling pathway
ubiquitin-dependent protein catabolic process - Gene Ontology Biological Process:
- cellular protein modification process
cellular response to hypoxia
Fc-epsilon receptor signaling pathway
innate immune response
MyD88-independent toll-like receptor signaling pathway
protein autoubiquitination
protein K48-linked ubiquitination
protein polyubiquitination
protein ubiquitination
regulation of transcription from RNA polymerase II promoter in response to hypoxia
stimulatory C-type lectin receptor signaling pathway
T cell receptor signaling pathway
toll-like receptor 3 signaling pathway
toll-like receptor 4 signaling pathway
toll-like receptor signaling pathway
TRIF-dependent toll-like receptor signaling pathway
ubiquitin-dependent protein catabolic process - Gene Ontology Molecular Function:
- ATP binding
ubiquitin conjugating enzyme activity
ubiquitin-protein transferase activity - Gene Ontology Cellular Component:
- cytosol
extracellular exosome
nucleoplasm
protein complex
ubiquitin ligase complex - Keywords:
- 3D-structure
ATP-binding
Alternative splicing
Complete proteome
Direct protein sequencing
Nucleotide-binding
Reference proteome
Transferase
Ubl conjugation pathway - Interacts With:
- O15151; Q99PZ6; Q96FW1; Q9Y3C5; Q68DV7; Q99942; Q9Y4K3; P98170; Q8ND25