Names & Taxonomy
- Uniprot ID:
- P62745
- Entry Name:
- RHOB_HUMAN
- Status:
- reviewed
- Protein Names:
- Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)
- Gene Names:
- RHOB ARH6 ARHB
- Gene Names Primary:
- RHOB
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 196
- Sequence:
- MAAIRKKLVVVGDGACGKTCLLIVFSKDEFPEVYVPTVFENYVADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSVDSPDSLENIPEKWVPEVKHFCPNVPIILVANKKDLRSDEHVRTELARMKQEPVRTDDGRAMAVRIQAYDYLECSAKTKEGVREVFETATRAALQKRYGSQNGCINCCKVL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Late endosome membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Nucleus. Cleavage furrow. Note=Late endosomal membrane (geranylgeranylated form). Plasma membrane (farnesylated form). Also detected at the nuclear margin and in the nucleus. Translocates to the equatorial region before furrow formation in a ECT2-dependent manner.
Function
- Function:
- Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells.
- Cross Reference Drug Bank:
- DB00083
- Gene Ontology Go:
- cleavage furrow
cytosol
early endosome
endosome membrane
extracellular exosome
focal adhesion
late endosome membrane
nucleus
plasma membrane
GDP binding
GTP binding
GTPase activity
angiogenesis
apoptotic process
axon guidance
blood coagulation
cell adhesion
cellular response to hydrogen peroxide
cellular response to ionizing radiation
cytokinesis
endosome to lysosome transport
endothelial tube morphogenesis
intracellular protein transport
negative regulation of cell cycle
negative regulation of cell migration
platelet activation
positive regulation of angiogenesis
positive regulation of apoptotic process
positive regulation of endothelial cell migration
regulation of cell migration
regulation of small GTPase mediated signal transduction
Rho protein signal transduction
small GTPase mediated signal transduction
transformed cell apoptotic process - Gene Ontology Biological Process:
- angiogenesis
apoptotic process
axon guidance
blood coagulation
cell adhesion
cellular response to hydrogen peroxide
cellular response to ionizing radiation
cytokinesis
endosome to lysosome transport
endothelial tube morphogenesis
intracellular protein transport
negative regulation of cell cycle
negative regulation of cell migration
platelet activation
positive regulation of angiogenesis
positive regulation of apoptotic process
positive regulation of endothelial cell migration
regulation of cell migration
regulation of small GTPase mediated signal transduction
Rho protein signal transduction
small GTPase mediated signal transduction
transformed cell apoptotic process - Gene Ontology Molecular Function:
- GDP binding
GTPase activity
GTP binding - Gene Ontology Cellular Component:
- cleavage furrow
cytosol
early endosome
endosome membrane
extracellular exosome
focal adhesion
late endosome membrane
nucleus
plasma membrane - Keywords:
- 3D-structure
ADP-ribosylation
Angiogenesis
Apoptosis
Cell adhesion
Cell membrane
Complete proteome
Developmental protein
Differentiation
Direct protein sequencing
Endosome
GTP-binding
Glycoprotein
Lipoprotein
Membrane
Methylation
Nucleotide-binding
Nucleus
Palmitate
Phosphoprotein
Prenylation
Protein transport
Reference proteome
Transport
Tumor suppressor - Interacts With:
- Q9HCE7-2; Q13829