Names & Taxonomy
- Uniprot ID:
- P61619
- Entry Name:
- S61A1_HUMAN
- Status:
- reviewed
- Protein Names:
- Protein transport protein Sec61 subunit alpha isoform 1 (Sec61 alpha-1)
- Gene Names:
- SEC61A1 SEC61A
- Gene Names Primary:
- SEC61A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 476
- Sequence:
- MAIKFLEVIKPFCVILPEIQKPERKIQFKEKVLWTAITLFIFLVCCQIPLFGIMSSDSADPFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFGMIITIGQSIVYVMTGMYGDPSEMGAGICLLITIQLFVAGLIVLLLDELLQKGYGLGSGISLFIATNICETIVWKAFSPTTVNTGRGMEFEGAIIALFHLLATRTDKVRALREAFYRQNLPNLMNLIATIFVFAVVIYFQGFRVDLPIKSARYRGQYNTYPIKLFYTSNIPIILQSALVSNLYVISQMLSARFSGNLLVSLLGTWSDTSSGGPARAYPVGGLCYYLSPPESFGSVLEDPVHAVVYIVFMLGSCAFFSKTWIEVSGSSAKDVAKQLKEQQMVMRGHRETSMVHELNRYIPTAAAFGGLCIGALSVLADFLGAIGSGTGILLAVTIIYQYFEIFVKEQSEVGSMGALLF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane; Multi-pass membrane protein.
Function
- Function:
- Plays a crucial role in the insertion of secretory and membrane polypeptides into the ER. Required for assembly of membrane and secretory proteins. Tightly associated with membrane-bound ribosomes, either directly or through adapter proteins.
- Gene Ontology Go:
- cytosol
integral component of endoplasmic reticulum membrane
membrane
rough endoplasmic reticulum
ribosome binding
antigen processing and presentation of exogenous peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
antigen processing and presentation of peptide antigen via MHC class I
cell growth
cellular protein metabolic process
endoplasmic reticulum organization
endoplasmic reticulum unfolded protein response
IRE1-mediated unfolded protein response
posttranslational protein targeting to membrane
protein targeting to ER
response to interferon-gamma
SRP-dependent cotranslational protein targeting to membrane - Gene Ontology Biological Process:
- antigen processing and presentation of exogenous peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
antigen processing and presentation of peptide antigen via MHC class I
cell growth
cellular protein metabolic process
endoplasmic reticulum organization
endoplasmic reticulum unfolded protein response
IRE1-mediated unfolded protein response
posttranslational protein targeting to membrane
protein targeting to ER
response to interferon-gamma
SRP-dependent cotranslational protein targeting to membrane - Gene Ontology Molecular Function:
- ribosome binding
- Gene Ontology Cellular Component:
- cytosol
integral component of endoplasmic reticulum membrane
membrane
rough endoplasmic reticulum - Keywords:
- Alternative splicing
Complete proteome
Endoplasmic reticulum
Membrane
Protein transport
Reference proteome
Translocation
Transmembrane
Transmembrane helix
Transport - Interacts With:
- P27824; P11021