Names & Taxonomy

Uniprot ID:
P61158
Entry Name:
ARP3_HUMAN
Status:
reviewed
Protein Names:
Actin-related protein 3 (Actin-like protein 3)
Gene Names:
ACTR3 ARP3
Gene Names Primary:
ACTR3
Organism:
Homo sapiens (Human)

Structure

Length:
418
Sequence:
MAGRLPACVVDCGTGYTKLGYAGNTEPQFIIPSCIAIKESAKVGDQAQRRVMKGVDDLDFFIGDEAIEKPTYATKWPIRHGIVEDWDLMERFMEQVIFKYLRAEPEDHYFLLTEPPLNTPENREYTAEIMFESFNVPGLYIAVQAVLALAASWTSRQVGERTLTGTVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLRDREVGIPPEQSLETAKAVKERYSYVCPDLVKEFNKYDTDGSKWIKQYTGINAISKKEFSIDVGYERFLGPEIFFHPEFANPDFTQPISEVVDEVIQNCPIDVRRPLYKNIVLSGGSTMFRDFGRRLQRDLKRTVDARLKLSEELSGGRLKPKPIDVQVITHHMQRYAVWFGGSMLASTPEFYQVCHTKKDYEEIGPSICRHNPVFGVMS
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm, cytoskeleton

Function

Function:
Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis.
Gene Ontology Go:
actin cytoskeleton
Arp2/3 protein complex
brush border
cell-cell junction
cytosol
extracellular exosome
focal adhesion
lamellipodium
membrane
ATP binding
structural constituent of cytoskeleton
Arp2/3 complex-mediated actin nucleation
asymmetric cell division
axon guidance
cilium morphogenesis
ephrin receptor signaling pathway
establishment or maintenance of cell polarity
Fc-gamma receptor signaling pathway involved in phagocytosis
innate immune response
meiotic chromosome movement towards spindle pole
meiotic cytokinesis
movement of cell or subcellular component
small GTPase mediated signal transduction
spindle localization
Gene Ontology Biological Process:
Arp2/3 complex-mediated actin nucleation
asymmetric cell division
axon guidance
cilium morphogenesis
ephrin receptor signaling pathway
establishment or maintenance of cell polarity
Fc-gamma receptor signaling pathway involved in phagocytosis
innate immune response
meiotic chromosome movement towards spindle pole
meiotic cytokinesis
movement of cell or subcellular component
small GTPase mediated signal transduction
spindle localization
Gene Ontology Molecular Function:
ATP binding
structural constituent of cytoskeleton
Gene Ontology Cellular Component:
actin cytoskeleton
Arp2/3 protein complex
brush border
cell-cell junction
cytosol
extracellular exosome
focal adhesion
lamellipodium
membrane
Keywords:
ATP-binding
Acetylation
Actin-binding
Cell projection
Cilium biogenesis/degradation
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Nucleotide-binding
Reference proteome
Interacts With:
P17535

Publication

PubMed ID:
9230079 14702039 15815621 15489334 9000076 11741539 15592455 18614018 19413330 19109554 19608861 20393563 21269460 24275569 25944712