Names & Taxonomy
- Uniprot ID:
- P61158
- Entry Name:
- ARP3_HUMAN
- Status:
- reviewed
- Protein Names:
- Actin-related protein 3 (Actin-like protein 3)
- Gene Names:
- ACTR3 ARP3
- Gene Names Primary:
- ACTR3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 418
- Sequence:
- MAGRLPACVVDCGTGYTKLGYAGNTEPQFIIPSCIAIKESAKVGDQAQRRVMKGVDDLDFFIGDEAIEKPTYATKWPIRHGIVEDWDLMERFMEQVIFKYLRAEPEDHYFLLTEPPLNTPENREYTAEIMFESFNVPGLYIAVQAVLALAASWTSRQVGERTLTGTVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLRDREVGIPPEQSLETAKAVKERYSYVCPDLVKEFNKYDTDGSKWIKQYTGINAISKKEFSIDVGYERFLGPEIFFHPEFANPDFTQPISEVVDEVIQNCPIDVRRPLYKNIVLSGGSTMFRDFGRRLQRDLKRTVDARLKLSEELSGGRLKPKPIDVQVITHHMQRYAVWFGGSMLASTPEFYQVCHTKKDYEEIGPSICRHNPVFGVMS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, cytoskeleton
Function
- Function:
- Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis.
- Gene Ontology Go:
- actin cytoskeleton
Arp2/3 protein complex
brush border
cell-cell junction
cytosol
extracellular exosome
focal adhesion
lamellipodium
membrane
ATP binding
structural constituent of cytoskeleton
Arp2/3 complex-mediated actin nucleation
asymmetric cell division
axon guidance
cilium morphogenesis
ephrin receptor signaling pathway
establishment or maintenance of cell polarity
Fc-gamma receptor signaling pathway involved in phagocytosis
innate immune response
meiotic chromosome movement towards spindle pole
meiotic cytokinesis
movement of cell or subcellular component
small GTPase mediated signal transduction
spindle localization - Gene Ontology Biological Process:
- Arp2/3 complex-mediated actin nucleation
asymmetric cell division
axon guidance
cilium morphogenesis
ephrin receptor signaling pathway
establishment or maintenance of cell polarity
Fc-gamma receptor signaling pathway involved in phagocytosis
innate immune response
meiotic chromosome movement towards spindle pole
meiotic cytokinesis
movement of cell or subcellular component
small GTPase mediated signal transduction
spindle localization - Gene Ontology Molecular Function:
- ATP binding
structural constituent of cytoskeleton - Gene Ontology Cellular Component:
- actin cytoskeleton
Arp2/3 protein complex
brush border
cell-cell junction
cytosol
extracellular exosome
focal adhesion
lamellipodium
membrane - Keywords:
- ATP-binding
Acetylation
Actin-binding
Cell projection
Cilium biogenesis/degradation
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Nucleotide-binding
Reference proteome - Interacts With:
- P17535