Names & Taxonomy
- Uniprot ID:
- P59768
- Entry Name:
- GBG2_HUMAN
- Status:
- reviewed
- Protein Names:
- Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (G gamma-I)
- Gene Names:
- GNG2
- Gene Names Primary:
- GNG2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 71
- Sequence:
- MASNNTASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENPFREKKFFCAIL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity).
- Cross Reference Drug Bank:
- DB01159
- Gene Ontology Go:
- extracellular exosome
heterotrimeric G-protein complex
membrane
plasma membrane
G-protein beta-subunit binding
signal transducer activity
adenylate cyclase-activating dopamine receptor signaling pathway
blood coagulation
cell proliferation
cellular response to catecholamine stimulus
cellular response to glucagon stimulus
cellular response to prostaglandin E stimulus
energy reserve metabolic process
platelet activation
small molecule metabolic process
synaptic transmission - Gene Ontology Biological Process:
- adenylate cyclase-activating dopamine receptor signaling pathway
blood coagulation
cell proliferation
cellular response to catecholamine stimulus
cellular response to glucagon stimulus
cellular response to prostaglandin E stimulus
energy reserve metabolic process
platelet activation
small molecule metabolic process
synaptic transmission - Gene Ontology Molecular Function:
- G-protein beta-subunit binding
signal transducer activity - Gene Ontology Cellular Component:
- extracellular exosome
heterotrimeric G-protein complex
membrane
plasma membrane - Keywords:
- 3D-structure
Acetylation
Cell membrane
Complete proteome
Lipoprotein
Membrane
Methylation
Prenylation
Reference proteome
Transducer