Names & Taxonomy
- Uniprot ID:
- P58872
- Entry Name:
- RHBL3_HUMAN
- Status:
- reviewed
- Protein Names:
- Rhomboid-related protein 3 (EC 3.4.21.105) (Ventrhoid transmembrane protein)
- Gene Names:
- RHBDL3 RHBDL4 VRHO
- Gene Names Primary:
- RHBDL3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 404
- Sequence:
- MGEHPSPGPAVAACAEAERIEELEPEAEERLPAAPEDHWKVLFDQFDPGNTGYISTGKFRSLLESHSSKLDPHKREVLLALADSHADGQIGYQDFVSLMSNKRSNSFRQAILQGNRRLSSKALLEEKGLSLSQRLIRHVAYETLPREIDRKWYYDSYTCCPPPWFMITVTLLEVAFFLYNGVSLGQFVLQVTHPRYLKNSLVYHPQLRAQVWRYLTYIFMHAGIEHLGLNVVLQLLVGVPLEMVHGATRIGLVYVAGVVAGSLAVSVADMTAPVVGSSGGVYALVSAHLANIVMNWSGMKCQFKLLRMAVALICMSMEFGRAVWLRFHPSAYPPCPHPSFVAHLGGVAVGITLGVVVLRNYEQRLQDQSLWWIFVAMYTVFVLFAVFWNIFAYTLLDLKLPPPP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.
- Catalytic Activity:
- Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.
- Active Site:
- ACT_SITE 278 278 Nucleophile.
- Gene Ontology Go:
- integral component of membrane
mitochondrial inner membrane
calcium ion binding
serine-type endopeptidase activity
protein processing - Gene Ontology Biological Process:
- protein processing
- Gene Ontology Molecular Function:
- calcium ion binding
serine-type endopeptidase activity - Gene Ontology Cellular Component:
- integral component of membrane
mitochondrial inner membrane - Keywords:
- Alternative splicing
Complete proteome
Hydrolase
Membrane
Polymorphism
Protease
Reference proteome
Repeat
Serine protease
Transmembrane
Transmembrane helix