Names & Taxonomy
- Uniprot ID:
- P56282
- Entry Name:
- DPOE2_HUMAN
- Status:
- reviewed
- Protein Names:
- DNA polymerase epsilon subunit 2 (EC 2.7.7.7) (DNA polymerase II subunit 2) (DNA polymerase epsilon subunit B)
- Gene Names:
- POLE2 DPE2
- Gene Names Primary:
- POLE2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 527
- Sequence:
- MAPERLRSRALSAFKLRGLLLRGEAIKYLTEALQSISELELEDKLEKIINAVEKQPLSSNMIERSVVEAAVQECSQSVDETIEHVFNIIGAFDIPRFVYNSERKKFLPLLMTNHPAPNLFGTPRDKAEMFRERYTILHQRTHRHELFTPPVIGSHPDESGSKFQLKTIETLLGSTTKIGDAIVLGMITQLKEGKFFLEDPTGTVQLDLSKAQFHSGLYTEACFVLAEGWFEDQVFHVNAFGFPPTEPSSTTRAYYGNINFFGGPSNTSVKTSAKLKQLEEENKDAMFVFLSDVWLDQVEVLEKLRIMFAGYSPAPPTCFILCGNFSSAPYGKNQVQALKDSLKTLADIICEYPDIHQSSRFVFVPGPEDPGFGSILPRPPLAESITNEFRQRVPFSVFTTNPCRIQYCTQEITVFREDLVNKMCRNCVRFPSSNLAIPNHFVKTILSQGHLTPLPLYVCPVYWAYDYALRVYPVPDLLVIADKYDPFTTTNTECLCINPGSFPRSGFSFKVFYPSNKTVEDSKLQGF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus.
Function
- Function:
- Participates in DNA repair and in chromosomal DNA replication.
- Catalytic Activity:
- Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
- Cross Reference Drug Bank:
- DB00242
- Gene Ontology Go:
- epsilon DNA polymerase complex
intracellular membrane-bounded organelle
nucleoplasm
DNA binding
DNA-directed DNA polymerase activity
DNA repair
DNA replication
DNA replication initiation
DNA-dependent DNA replication
error-prone translesion synthesis
G1/S transition of mitotic cell cycle
mitotic cell cycle
telomere maintenance
telomere maintenance via recombination
telomere maintenance via semi-conservative replication - Gene Ontology Biological Process:
- DNA-dependent DNA replication
DNA repair
DNA replication
DNA replication initiation
error-prone translesion synthesis
G1/S transition of mitotic cell cycle
mitotic cell cycle
telomere maintenance
telomere maintenance via recombination
telomere maintenance via semi-conservative replication - Gene Ontology Molecular Function:
- DNA binding
DNA-directed DNA polymerase activity - Gene Ontology Cellular Component:
- epsilon DNA polymerase complex
intracellular membrane-bounded organelle
nucleoplasm - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
DNA replication
DNA-binding
DNA-directed DNA polymerase
Nucleotidyltransferase
Nucleus
Polymorphism
Reference proteome
Transferase - Interacts With:
- P52594; V9HWB8; Q15691; Q04864; Q96SF7; P14373