Names & Taxonomy

Uniprot ID:
P56282
Entry Name:
DPOE2_HUMAN
Status:
reviewed
Protein Names:
DNA polymerase epsilon subunit 2 (EC 2.7.7.7) (DNA polymerase II subunit 2) (DNA polymerase epsilon subunit B)
Gene Names:
POLE2 DPE2
Gene Names Primary:
POLE2
Organism:
Homo sapiens (Human)

Structure

Length:
527
Sequence:
MAPERLRSRALSAFKLRGLLLRGEAIKYLTEALQSISELELEDKLEKIINAVEKQPLSSNMIERSVVEAAVQECSQSVDETIEHVFNIIGAFDIPRFVYNSERKKFLPLLMTNHPAPNLFGTPRDKAEMFRERYTILHQRTHRHELFTPPVIGSHPDESGSKFQLKTIETLLGSTTKIGDAIVLGMITQLKEGKFFLEDPTGTVQLDLSKAQFHSGLYTEACFVLAEGWFEDQVFHVNAFGFPPTEPSSTTRAYYGNINFFGGPSNTSVKTSAKLKQLEEENKDAMFVFLSDVWLDQVEVLEKLRIMFAGYSPAPPTCFILCGNFSSAPYGKNQVQALKDSLKTLADIICEYPDIHQSSRFVFVPGPEDPGFGSILPRPPLAESITNEFRQRVPFSVFTTNPCRIQYCTQEITVFREDLVNKMCRNCVRFPSSNLAIPNHFVKTILSQGHLTPLPLYVCPVYWAYDYALRVYPVPDLLVIADKYDPFTTTNTECLCINPGSFPRSGFSFKVFYPSNKTVEDSKLQGF
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Nucleus.

Function

Function:
Participates in DNA repair and in chromosomal DNA replication.
Catalytic Activity:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
Cross Reference Drug Bank:
DB00242
Gene Ontology Go:
epsilon DNA polymerase complex
intracellular membrane-bounded organelle
nucleoplasm
DNA binding
DNA-directed DNA polymerase activity
DNA repair
DNA replication
DNA replication initiation
DNA-dependent DNA replication
error-prone translesion synthesis
G1/S transition of mitotic cell cycle
mitotic cell cycle
telomere maintenance
telomere maintenance via recombination
telomere maintenance via semi-conservative replication
Gene Ontology Biological Process:
DNA-dependent DNA replication
DNA repair
DNA replication
DNA replication initiation
error-prone translesion synthesis
G1/S transition of mitotic cell cycle
mitotic cell cycle
telomere maintenance
telomere maintenance via recombination
telomere maintenance via semi-conservative replication
Gene Ontology Molecular Function:
DNA binding
DNA-directed DNA polymerase activity
Gene Ontology Cellular Component:
epsilon DNA polymerase complex
intracellular membrane-bounded organelle
nucleoplasm
Keywords:
3D-structure
Alternative splicing
Complete proteome
DNA replication
DNA-binding
DNA-directed DNA polymerase
Nucleotidyltransferase
Nucleus
Polymorphism
Reference proteome
Transferase
Interacts With:
P52594; V9HWB8; Q15691; Q04864; Q96SF7; P14373

Publication

PubMed ID:
9405441 9443964 11433027 14702039 12508121 15489334 10801849