Names & Taxonomy
- Uniprot ID:
- P56192
- Entry Name:
- SYMC_HUMAN
- Status:
- reviewed
- Protein Names:
- Methionine--tRNA ligase, cytoplasmic (EC 6.1.1.10) (Methionyl-tRNA synthetase) (MetRS)
- Gene Names:
- MARS
- Gene Names Primary:
- MARS
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 900
- Sequence:
- MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Catalytic Activity:
- ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met).
- Cross Reference Drug Bank:
- DB00134
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
membrane
ATP binding
methionine-tRNA ligase activity
tRNA binding
cellular nitrogen compound metabolic process
gene expression
methionyl-tRNA aminoacylation
selenium compound metabolic process
small molecule metabolic process
tRNA aminoacylation for protein translation - Gene Ontology Biological Process:
- cellular nitrogen compound metabolic process
gene expression
methionyl-tRNA aminoacylation
selenium compound metabolic process
small molecule metabolic process
tRNA aminoacylation for protein translation - Gene Ontology Molecular Function:
- ATP binding
methionine-tRNA ligase activity
tRNA binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome
membrane - Keywords:
- 3D-structure
ATP-binding
Alternative splicing
Aminoacyl-tRNA synthetase
Charcot-Marie-Tooth disease
Complete proteome
Cytoplasm
Disease mutation
Ligase
Neurodegeneration
Neuropathy
Nucleotide-binding
Phosphoprotein
Polymorphism
Protein biosynthesis
RNA-binding
Reference proteome
tRNA-binding