Names & Taxonomy

Uniprot ID:
P55809
Entry Name:
SCOT1_HUMAN
Status:
reviewed
Protein Names:
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial (EC 2.8.3.5) (3-oxoacid CoA-transferase 1) (Somatic-type succinyl-CoA:3-oxoacid CoA-transferase) (SCOT-s)
Gene Names:
OXCT1 OXCT SCOT
Gene Names Primary:
OXCT1
Organism:
Homo sapiens (Human)

Structure

Length:
520
Sequence:
MAALKLLSSGLRLCASARGSGATWYKGCVCSFSTSAHRHTKFYTDPVEAVKDIPDGATVLVGGFGLCGIPENLIDALLKTGVKGLTAVSNNAGVDNFGLGLLLRSKQIKRMVSSYVGENAEFERQYLSGELEVELTPQGTLAERIRAGGAGVPAFYTPTGYGTLVQEGGSPIKYNKDGSVAIASKPREVREFNGQHFILEEAITGDFALVKAWKADRAGNVIFRKSARNFNLPMCKAAETTVVEVEEIVDIGAFAPEDIHIPQIYVHRLIKGEKYEKRIERLSIRKEGDGEAKSAKPGDDVRERIIKRAALEFEDGMYANLGIGIPLLASNFISPNITVHLQSENGVLGLGPYPRQHEADADLINAGKETVTILPGASFFSSDESFAMIRGGHVDLTMLGAMQVSKYGDLANWMIPGKMVKGMGGAMDLVSSAKTKVVVTMEHSAKGNAHKIMEKCTLPLTGKQCVNRIITEKAVFDVDKKKGLTLIELWEGLTVDDVQKSTGCDFAVSPKLMPMQQIAN
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Mitochondrion matrix.

Function

Function:
Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
Pathway:
Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.
Catalytic Activity:
Succinyl-CoA + a 3-oxo acid = succinate + a 3-oxoacyl-CoA.
Active Site:
ACT_SITE 344 344 5-glutamyl coenzyme A thioester intermediate.
Cross Reference Drug Bank:
DB00139
Gene Ontology Go:
mitochondrial matrix
mitochondrion
3-oxoacid CoA-transferase activity
protein homodimerization activity
adipose tissue development
brain development
cellular ketone body metabolic process
cellular lipid metabolic process
heart development
ketone body catabolic process
ketone catabolic process
positive regulation of insulin secretion involved in cellular response to glucose stimulus
response to activity
response to drug
response to ethanol
response to hormone
response to nutrient
response to starvation
small molecule metabolic process
Gene Ontology Biological Process:
adipose tissue development
brain development
cellular ketone body metabolic process
cellular lipid metabolic process
heart development
ketone body catabolic process
ketone catabolic process
positive regulation of insulin secretion involved in cellular response to glucose stimulus
response to activity
response to drug
response to ethanol
response to hormone
response to nutrient
response to starvation
small molecule metabolic process
Gene Ontology Molecular Function:
3-oxoacid CoA-transferase activity
protein homodimerization activity
Gene Ontology Cellular Component:
mitochondrial matrix
mitochondrion
Keywords:
3D-structure
Alternative splicing
Complete proteome
Direct protein sequencing
Disease mutation
Mitochondrion
Phosphoprotein
Polymorphism
Reference proteome
Transferase
Transit peptide

Publication

PubMed ID:
8751852 10964512 15372022 14702039 15489334 19608861 20068231 21269460 25944712 9671268 21296660