Names & Taxonomy
- Uniprot ID:
- P55809
- Entry Name:
- SCOT1_HUMAN
- Status:
- reviewed
- Protein Names:
- Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial (EC 2.8.3.5) (3-oxoacid CoA-transferase 1) (Somatic-type succinyl-CoA:3-oxoacid CoA-transferase) (SCOT-s)
- Gene Names:
- OXCT1 OXCT SCOT
- Gene Names Primary:
- OXCT1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 520
- Sequence:
- MAALKLLSSGLRLCASARGSGATWYKGCVCSFSTSAHRHTKFYTDPVEAVKDIPDGATVLVGGFGLCGIPENLIDALLKTGVKGLTAVSNNAGVDNFGLGLLLRSKQIKRMVSSYVGENAEFERQYLSGELEVELTPQGTLAERIRAGGAGVPAFYTPTGYGTLVQEGGSPIKYNKDGSVAIASKPREVREFNGQHFILEEAITGDFALVKAWKADRAGNVIFRKSARNFNLPMCKAAETTVVEVEEIVDIGAFAPEDIHIPQIYVHRLIKGEKYEKRIERLSIRKEGDGEAKSAKPGDDVRERIIKRAALEFEDGMYANLGIGIPLLASNFISPNITVHLQSENGVLGLGPYPRQHEADADLINAGKETVTILPGASFFSSDESFAMIRGGHVDLTMLGAMQVSKYGDLANWMIPGKMVKGMGGAMDLVSSAKTKVVVTMEHSAKGNAHKIMEKCTLPLTGKQCVNRIITEKAVFDVDKKKGLTLIELWEGLTVDDVQKSTGCDFAVSPKLMPMQQIAN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion matrix.
Function
- Function:
- Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
- Pathway:
- Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.
- Catalytic Activity:
- Succinyl-CoA + a 3-oxo acid = succinate + a 3-oxoacyl-CoA.
- Active Site:
- ACT_SITE 344 344 5-glutamyl coenzyme A thioester intermediate.
- Cross Reference Drug Bank:
- DB00139
- Gene Ontology Go:
- mitochondrial matrix
mitochondrion
3-oxoacid CoA-transferase activity
protein homodimerization activity
adipose tissue development
brain development
cellular ketone body metabolic process
cellular lipid metabolic process
heart development
ketone body catabolic process
ketone catabolic process
positive regulation of insulin secretion involved in cellular response to glucose stimulus
response to activity
response to drug
response to ethanol
response to hormone
response to nutrient
response to starvation
small molecule metabolic process - Gene Ontology Biological Process:
- adipose tissue development
brain development
cellular ketone body metabolic process
cellular lipid metabolic process
heart development
ketone body catabolic process
ketone catabolic process
positive regulation of insulin secretion involved in cellular response to glucose stimulus
response to activity
response to drug
response to ethanol
response to hormone
response to nutrient
response to starvation
small molecule metabolic process - Gene Ontology Molecular Function:
- 3-oxoacid CoA-transferase activity
protein homodimerization activity - Gene Ontology Cellular Component:
- mitochondrial matrix
mitochondrion - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Direct protein sequencing
Disease mutation
Mitochondrion
Phosphoprotein
Polymorphism
Reference proteome
Transferase
Transit peptide