Names & Taxonomy
- Uniprot ID:
- P55283
- Entry Name:
- CADH4_HUMAN
- Status:
- reviewed
- Protein Names:
- Cadherin-4 (Retinal cadherin) (R-CAD) (R-cadherin)
- Gene Names:
- CDH4
- Gene Names Primary:
- CDH4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 916
- Sequence:
- MTAGAGVLLLLLSLSGALRAHNEDLTTRETCKAGFSEDDYTALISQNILEGEKLLQVKFSSCVGTKGTQYETNSMDFKVGADGTVFATRELQVPSEQVAFTVTAWDSQTAEKWDAVVRLLVAQTSSPHSGHKPQKGKKVVALDPSPPPKDTLLPWPQHQNANGLRRRKRDWVIPPINVPENSRGPFPQQLVRIRSDKDNDIPIRYSITGVGADQPPMEVFSIDSMSGRMYVTRPMDREEHASYHLRAHAVDMNGNKVENPIDLYIYVIDMNDNRPEFINQVYNGSVDEGSKPGTYVMTVTANDADDSTTANGMVRYRIVTQTPQSPSQNMFTINSETGDIVTVAAGLDREKVQQYTVIVQATDMEGNLNYGLSNTATAIITVTDVNDNPPEFTASTFAGEVPENRVETVVANLTVMDRDQPHSPNWNAVYRIISGDPSGHFSVRTDPVTNEGMVTVVKAVDYELNRAFMLTVMVSNQAPLASGIQMSFQSTAGVTISIMDINEAPYFPSNHKLIRLEEGVPPGTVLTTFSAVDPDRFMQQAVRYSKLSDPASWLHINATNGQITTAAVLDRESLYTKNNVYEATFLAADNGIPPASGTGTLQIYLIDINDNAPELLPKEAQICEKPNLNAINITAADADVDPNIGPYVFELPFVPAAVRKNWTITRLNGDYAQLSLRILYLEAGMYDVPIIVTDSGNPPLSNTSIIKVKVCPCDDNGDCTTIGAVAAAGLGTGAIVAILICILILLTMVLLFVMWMKRREKERHTKQLLIDPEDDVRDNILKYDEEGGGEEDQDYDLSQLQQPEAMGHVPSKAPGVRRVDERPVGAEPQYPIRPMVPHPGDIGDFINEGLRAADNDPTAPPYDSLLVFDYEGSGSTAGSVSSLNSSSSGDQDYDYLNDWGPRFKKLADMYGGGEED
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Single-pass type I membrane protein.
Function
- Function:
- Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development.
- Gene Ontology Go:
- integral component of plasma membrane
plasma membrane
calcium ion binding
adherens junction organization
axon guidance
cell adhesion
cell junction assembly
cell-cell junction organization
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
homophilic cell adhesion via plasma membrane adhesion molecules
positive regulation of axon extension - Gene Ontology Biological Process:
- adherens junction organization
axon guidance
cell adhesion
cell-cell junction organization
cell junction assembly
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
homophilic cell adhesion via plasma membrane adhesion molecules
positive regulation of axon extension - Gene Ontology Molecular Function:
- calcium ion binding
- Gene Ontology Cellular Component:
- integral component of plasma membrane
plasma membrane - Keywords:
- Alternative splicing
Calcium
Cell adhesion
Cell membrane
Cleavage on pair of basic residues
Complete proteome
Glycoprotein
Membrane
Metal-binding
Polymorphism
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix