Names & Taxonomy
- Uniprot ID:
- P55263
- Entry Name:
- ADK_HUMAN
- Status:
- reviewed
- Protein Names:
- Adenosine kinase (AK) (EC 2.7.1.20) (Adenosine 5'-phosphotransferase)
- Gene Names:
- ADK
- Gene Names Primary:
- ADK
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 362
- Sequence:
- MAAAEEEPKPKKLKVEAPQALRENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPDFH
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform 1: Nucleus
Function
- Function:
- ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.
- Pathway:
- Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.
- Catalytic Activity:
- ATP + adenosine = ADP + AMP.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; ; Note=Binds 3 Mg(2+) ions per subunit.;
- Active Site:
- ACT_SITE 317 317
- Cross Reference Drug Bank:
- DB01048 DB00640 DB00131 DB00171 DB00811
- Gene Ontology Go:
- cytoplasm
cytosol
nucleoplasm
adenosine kinase activity
ATP binding
metal ion binding
poly(A) RNA binding
adenosine metabolic process
AMP salvage
circadian regulation of gene expression
dATP biosynthetic process
nucleobase-containing small molecule metabolic process
positive regulation of cardiac muscle hypertrophy
positive regulation of T cell proliferation
purine nucleobase metabolic process
purine-containing compound salvage
ribonucleoside monophosphate biosynthetic process
small molecule metabolic process
type B pancreatic cell proliferation - Gene Ontology Biological Process:
- adenosine metabolic process
AMP salvage
circadian regulation of gene expression
dATP biosynthetic process
nucleobase-containing small molecule metabolic process
positive regulation of cardiac muscle hypertrophy
positive regulation of T cell proliferation
purine-containing compound salvage
purine nucleobase metabolic process
ribonucleoside monophosphate biosynthetic process
small molecule metabolic process
type B pancreatic cell proliferation - Gene Ontology Molecular Function:
- adenosine kinase activity
ATP binding
metal ion binding
poly(A) RNA binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol
nucleoplasm - Keywords:
- 3D-structure
ATP-binding
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Direct protein sequencing
Disease mutation
Kinase
Magnesium
Metal-binding
Nucleotide-binding
Nucleus
Phosphoprotein
Purine salvage
Reference proteome
Transferase