Names & Taxonomy
- Uniprot ID:
- P55087
- Entry Name:
- AQP4_HUMAN
- Status:
- reviewed
- Protein Names:
- Aquaporin-4 (AQP-4) (Mercurial-insensitive water channel) (MIWC) (WCH4)
- Gene Names:
- AQP4
- Gene Names Primary:
- AQP4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 323
- Sequence:
- MSDRPTARRWGKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWGGTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVHVIDVDRGEEKKGKDQSGEVLSSV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
Function
- Function:
- Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system.
- Gene Ontology Go:
- basolateral plasma membrane
cytoplasm
external side of plasma membrane
integral component of membrane
plasma membrane
glycerol channel activity
water channel activity
water transmembrane transporter activity
cellular response to interferon-gamma
glycerol transport
ion transmembrane transport
multicellular organismal water homeostasis
renal water homeostasis
transmembrane transport
transport
water transport - Gene Ontology Biological Process:
- cellular response to interferon-gamma
glycerol transport
ion transmembrane transport
multicellular organismal water homeostasis
renal water homeostasis
transmembrane transport
transport
water transport - Gene Ontology Molecular Function:
- glycerol channel activity
water channel activity
water transmembrane transporter activity - Gene Ontology Cellular Component:
- basolateral plasma membrane
cytoplasm
external side of plasma membrane
integral component of membrane
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Glycoprotein
Membrane
Phosphoprotein
Reference proteome
Repeat
Transmembrane
Transmembrane helix
Transport