Names & Taxonomy

Uniprot ID:
P55017
Entry Name:
S12A3_HUMAN
Status:
reviewed
Protein Names:
Solute carrier family 12 member 3 (Na-Cl cotransporter) (NCC) (Na-Cl symporter) (Thiazide-sensitive sodium-chloride cotransporter)
Gene Names:
SLC12A3 NCC TSC
Gene Names Primary:
SLC12A3
Organism:
Homo sapiens (Human)

Structure

Length:
1021
Sequence:
MAELPTTETPGDATLCSGRFTISTLLSSDEPSPPAAYDSSHPSHLTHSSTFCMRTFGYNTIDVVPTYEHYANSTQPGEPRKVRPTLADLHSFLKQEGRHLHALAFDSRPSHEMTDGLVEGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAETVRDLLQEYGAPIVDPINDIRIIAVVSVTVLLAISLAGMEWESKAQVLFFLVIMVSFANYLVGTLIPPSEDKASKGFFSYRADIFVQNLVPDWRGPDGTFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSCVVRDASGVLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHIKNYRPQCLVLTGPPNFRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPELQLIANGHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNWQSAHPATVEDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHINPVFDPAEDGKEASARVDPKALVKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVFVGGQINRMDQERKAIISLLSKFRLGFHEVHILPDINQNPRAEHTKRFEDMIAPFRLNDGFKDEATVNEMRRDCPWKISDEEITKNRVKSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDLRPPVILIRGNQENVLTFYCQ
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Function

Function:
Key mediator of sodium and chloride reabsorption in this nephron segment, accounting for a significant fraction of renal sodium reabsorption.
Enzyme Regulation:
ENZYME REGULATION: Activated by WNK3.
Cross Reference Drug Bank:
DB00436 DB00562 DB00880 DB01119 DB00999 DB00524 DB01324 DB01325
Gene Ontology Go:
apical plasma membrane
cytosol
extracellular exosome
integral component of plasma membrane
membrane
plasma membrane
sodium:chloride symporter activity
transporter activity
ion transport
sodium ion transmembrane transport
sodium ion transport
transmembrane transport
transport
Gene Ontology Biological Process:
ion transport
sodium ion transmembrane transport
sodium ion transport
transmembrane transport
transport
Gene Ontology Molecular Function:
sodium:chloride symporter activity
transporter activity
Gene Ontology Cellular Component:
apical plasma membrane
cytosol
extracellular exosome
integral component of plasma membrane
membrane
plasma membrane
Keywords:
Alternative splicing
Cell membrane
Complete proteome
Disease mutation
Glycoprotein
Ion transport
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Sodium
Sodium transport
Symport
Transmembrane
Transmembrane helix
Transport
Ubl conjugation

Publication

PubMed ID:
8528245 8812482 14702039 15616553 21613606 8900229 22406640 8954067 9734597 10988270 10616841 11168953 11940055 12008755 12112667 15069170 15687331 16429844 17654016 17873326 17885550