Names & Taxonomy
- Uniprot ID:
- P54753
- Entry Name:
- EPHB3_HUMAN
- Status:
- reviewed
- Protein Names:
- Ephrin type-B receptor 3 (EC 2.7.10.1) (EPH-like tyrosine kinase 2) (EPH-like kinase 2) (Embryonic kinase 2) (EK2) (hEK2) (Tyrosine-protein kinase TYRO6)
- Gene Names:
- EPHB3 ETK2 HEK2 TYRO6
- Gene Names Primary:
- EPHB3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 998
- Sequence:
- MARARPPPPPSPPPGLLPLLPPLLLLPLLLLPAGCRALEETLMDTKWVTSELAWTSHPESGWEEVSGYDEAMNPIRTYQVCNVRESSQNNWLRTGFIWRRDVQRVYVELKFTVRDCNSIPNIPGSCKETFNLFYYEADSDVASASSPFWMENPYVKVDTIAPDESFSRLDAGRVNTKVRSFGPLSKAGFYLAFQDQGACMSLISVRAFYKKCASTTAGFALFPETLTGAEPTSLVIAPGTCIPNAVEVSVPLKLYCNGDGEWMVPVGACTCATGHEPAAKESQCRPCPPGSYKAKQGEGPCLPCPPNSRTTSPAASICTCHNNFYRADSDSADSACTTVPSPPRGVISNVNETSLILEWSEPRDLGGRDDLLYNVICKKCHGAGGASACSRCDDNVEFVPRQLGLTERRVHISHLLAHTRYTFEVQAVNGVSGKSPLPPRYAAVNITTNQAAPSEVPTLRLHSSSGSSLTLSWAPPERPNGVILDYEMKYFEKSEGIASTVTSQMNSVQLDGLRPDARYVVQVRARTVAGYGQYSRPAEFETTSERGSGAQQLQEQLPLIVGSATAGLVFVVAVVVIAIVCLRKQRHGSDSEYTEKLQQYIAPGMKVYIDPFTYEDPNEAVREFAKEIDVSCVKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCPTALHQLMLDCWVRDRNLRPKFSQIVNTLDKLIRNAASLKVIASAQSGMSQPLLDRTVPDYTTFTTVGDWLDAIKMGRYKESFVSAGFASFDLVAQMTAEDLLRIGVTLAGHQKKILSSIQDMRLQMNQTLPVQV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobes of the cerebral cortex. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development through regulation of cell migration and positioning. This includes angiogenesis, palate development and thymic epithelium development for instance. Forward and reverse signaling through the EFNB2/EPHB3 complex also regulate migration and adhesion of cells that tubularize the urethra and septate the cloaca. Finally, plays an important role in intestinal epithelium differentiation segregating progenitor from differentiated cells in the crypt.
- Catalytic Activity:
- ATP + a -L-tyrosine = ADP + a -L-tyrosine phosphate.
- Active Site:
- ACT_SITE 758 758 Proton acceptor.
- Gene Ontology Go:
- cytosol
dendrite
extracellular region
integral component of plasma membrane
plasma membrane
ATP binding
axon guidance receptor activity
ephrin receptor activity
angiogenesis
axon guidance
axonal fasciculation
cell migration
central nervous system projection neuron axonogenesis
corpus callosum development
dendritic spine development
dendritic spine morphogenesis
digestive tract morphogenesis
ephrin receptor signaling pathway
palate development
positive regulation of synapse assembly
protein autophosphorylation
regulation of axonogenesis
regulation of cell-cell adhesion
regulation of GTPase activity
retinal ganglion cell axon guidance
substrate adhesion-dependent cell spreading
thymus development
urogenital system development - Gene Ontology Biological Process:
- angiogenesis
axonal fasciculation
axon guidance
cell migration
central nervous system projection neuron axonogenesis
corpus callosum development
dendritic spine development
dendritic spine morphogenesis
digestive tract morphogenesis
ephrin receptor signaling pathway
palate development
positive regulation of synapse assembly
protein autophosphorylation
regulation of axonogenesis
regulation of cell-cell adhesion
regulation of GTPase activity
retinal ganglion cell axon guidance
substrate adhesion-dependent cell spreading
thymus development
urogenital system development - Gene Ontology Molecular Function:
- ATP binding
axon guidance receptor activity
ephrin receptor activity - Gene Ontology Cellular Component:
- cytosol
dendrite
extracellular region
integral component of plasma membrane
plasma membrane - Keywords:
- 3D-structure
ATP-binding
Angiogenesis
Cell membrane
Cell projection
Complete proteome
Developmental protein
Disulfide bond
Glycoprotein
Kinase
Membrane
Neurogenesis
Nucleotide-binding
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Transferase
Transmembrane
Transmembrane helix
Tyrosine-protein kinase