Names & Taxonomy

Uniprot ID:
P54687
Entry Name:
BCAT1_HUMAN
Status:
reviewed
Protein Names:
Branched-chain-amino-acid aminotransferase, cytosolic (BCAT(c)) (EC 2.6.1.42) (Protein ECA39)
Gene Names:
BCAT1 BCT1 ECA39
Gene Names Primary:
BCAT1
Organism:
Homo sapiens (Human)

Structure

Length:
386
Sequence:
MKDCSNGCSAECTGEGGSKEVVGTFKAKDLIVTPATILKEKPDPNNLVFGTVFTDHMLTVEWSSEFGWEKPHIKPLQNLSLHPGSSALHYAVELFEGLKAFRGVDNKIRLFQPNLNMDRMYRSAVRATLPVFDKEELLECIQQLVKLDQEWVPYSTSASLYIRPTFIGTEPSLGVKKPTKALLFVLLSPVGPYFSSGTFNPVSLWANPKYVRAWKGGTGDCKMGGNYGSSLFAQCEAVDNGCQQVLWLYGEDHQITEVGTMNLFLYWINEDGEEELATPPLDGIILPGVTRRCILDLAHQWGEFKVSERYLTMDDLTTALEGNRVREMFGSGTACVVCPVSDILYKGETIHIPTMENGPKLASRILSKLTDIQYGREESDWTIVLS
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm.

Function

Function:
Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.
Catalytic Activity:
L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate.; L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate.; L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate.
Cofactor:
COFACTOR: Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
Cross Reference Drug Bank:
DB00996 DB00167 DB00149 DB00161
Gene Ontology Go:
cytosol
branched-chain-amino-acid transaminase activity
L-isoleucine transaminase activity
L-leucine transaminase activity
L-valine transaminase activity
branched-chain amino acid biosynthetic process
branched-chain amino acid catabolic process
cell proliferation
cellular nitrogen compound metabolic process
G1/S transition of mitotic cell cycle
small molecule metabolic process
Gene Ontology Biological Process:
branched-chain amino acid biosynthetic process
branched-chain amino acid catabolic process
cell proliferation
cellular nitrogen compound metabolic process
G1/S transition of mitotic cell cycle
small molecule metabolic process
Gene Ontology Molecular Function:
branched-chain-amino-acid transaminase activity
L-isoleucine transaminase activity
L-leucine transaminase activity
L-valine transaminase activity
Gene Ontology Cellular Component:
cytosol
Keywords:
3D-structure
Acetylation
Alternative splicing
Amino-acid biosynthesis
Aminotransferase
Branched-chain amino acid biosynthesis
Complete proteome
Cytoplasm
Polymorphism
Pyridoxal phosphate
Reference proteome
Transferase

Publication

PubMed ID:
8692959 14702039 17974005 16541075 19413330 21269460 16141215 16143519