Names & Taxonomy
- Uniprot ID:
- P54289
- Entry Name:
- CA2D1_HUMAN
- Status:
- reviewed
- Protein Names:
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (Voltage-gated calcium channel subunit alpha-2/delta-1) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-1; Voltage-dependent calcium channel subunit delta-1]
- Gene Names:
- CACNA2D1 CACNL2A CCHL2A MHS3
- Gene Names Primary:
- CACNA2D1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1103
- Sequence:
- MAAGCLLALTLTLFQSLLIGPSSEEPFPSAVTIKSWVDKMQEDLVTLAKTASGVNQLVDIYEKYQDLYTVEPNNARQLVEIAARDIEKLLSNRSKALVRLALEAEKVQAAHQWREDFASNEVVYYNAKDDLDPEKNDSEPGSQRIKPVFIEDANFGRQISYQHAAVHIPTDIYEGSTIVLNELNWTSALDEVFKKNREEDPSLLWQVFGSATGLARYYPASPWVDNSRTPNKIDLYDVRRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQDVSCFQHLVQANVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQLLNYNVSRANCNKIIMLFTDGGEERAQEIFNKYNKDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIRINTQEYLDVLGRPMVLAGDKAKQVQWTNVYLDALELGLVITGTLPVFNITGQFENKTNLKNQLILGVMGVDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQPKPIGVGIPTINLRKRRPNIQNPKSQEPVTLDFLDAELENDIKVEIRNKMIDGESGEKTFRTLVKSQDERYIDKGNRTYTWTPVNGTDYSLALVLPTYSFYYIKAKLEETITQARYSETLKPDNFEESGYTFIAPRDYCNDLKISDNNTEFLLNFNEFIDRKTPNNPSCNADLINRVLLDAGFTNELVQNYWSKQKNIKGVKARFVVTDGGITRVYPKEAGENWQENPETYEDSFYKRSLDNDNYVFTAPYFNKSGPGAYESGIMVSKAVEIYIQGKLLKPAVVGIKIDVNSWIENFTKTSIRDPCAGPVCDCKRNSDVMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPSLMRHLVNISVYAFNKSYDYQSVCEPGAAPKQGAGHRSAYVPSVADILQIGWWATAAAWSILQQFLLSLTFPRLLEAVEMEDDDFTASLSKQSCITEQTQYFFDNDSKSFSGVLDCGNCSRIFHGEKLMNTNLIFIMVESKGTCPCDTRLLIQAEQTSDGPNPCDMVKQPRYRKGPDVCFDNNVLEDYTDCGGVSGLNPSLWYIIGIQFLLLWLVSGSTHRLL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling (By similarity).
- Cross Reference Drug Bank:
- DB00381 DB04838 DB01023 DB00996 DB00308 DB00270 DB00653 DB00622 DB01115 DB06712 DB00401 DB01054 DB00421
- Gene Ontology Go:
- extracellular exosome
L-type voltage-gated calcium channel complex
plasma membrane
sarcoplasmic reticulum
voltage-gated calcium channel complex
metal ion binding
voltage-gated calcium channel activity
calcium ion transport
cardiac conduction
regulation of calcium ion transport - Gene Ontology Biological Process:
- calcium ion transport
cardiac conduction
regulation of calcium ion transport - Gene Ontology Molecular Function:
- metal ion binding
voltage-gated calcium channel activity - Gene Ontology Cellular Component:
- extracellular exosome
L-type voltage-gated calcium channel complex
plasma membrane
sarcoplasmic reticulum
voltage-gated calcium channel complex - Keywords:
- Alternative splicing
Calcium
Calcium channel
Calcium transport
Complete proteome
Disulfide bond
Glycoprotein
Ion channel
Ion transport
Membrane
Metal-binding
Phosphoprotein
Polymorphism
Reference proteome
Signal
Transmembrane
Transmembrane helix
Transport
Voltage-gated channel