Names & Taxonomy
- Uniprot ID:
- P53582
- Entry Name:
- MAP11_HUMAN
- Status:
- reviewed
- Protein Names:
- Methionine aminopeptidase 1 (MAP 1) (MetAP 1) (EC 3.4.11.18) (Peptidase M 1)
- Gene Names:
- METAP1 KIAA0094
- Gene Names Primary:
- METAP1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 386
- Sequence:
- MAAVETRVCETDGCSSEAKLQCPTCIKLGIQGSYFCSQECFKGSWATHKLLHKKAKDEKAKREVSSWTVEGDINTDPWAGYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMSQF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle.
- Catalytic Activity:
- Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
- Cofactor:
- COFACTOR: Name=Co(2+); Xref=ChEBI:CHEBI:48828;
- Gene Ontology Go:
- cytoplasm
cytosol
nucleus
aminopeptidase activity
metal ion binding
metalloexopeptidase activity
N-terminal protein amino acid modification
peptidyl-methionine modification
phototransduction, visible light
platelet aggregation
regulation of rhodopsin mediated signaling pathway
regulation of translation
rhodopsin mediated signaling pathway - Gene Ontology Biological Process:
- N-terminal protein amino acid modification
peptidyl-methionine modification
phototransduction, visible light
platelet aggregation
regulation of rhodopsin mediated signaling pathway
regulation of translation
rhodopsin mediated signaling pathway - Gene Ontology Molecular Function:
- aminopeptidase activity
metal ion binding
metalloexopeptidase activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
nucleus - Keywords:
- 3D-structure
Acetylation
Aminopeptidase
Complete proteome
Cytoplasm
Hydrolase
Metal-binding
Protease
Reference proteome