Names & Taxonomy

Uniprot ID:
P53582
Entry Name:
MAP11_HUMAN
Status:
reviewed
Protein Names:
Methionine aminopeptidase 1 (MAP 1) (MetAP 1) (EC 3.4.11.18) (Peptidase M 1)
Gene Names:
METAP1 KIAA0094
Gene Names Primary:
METAP1
Organism:
Homo sapiens (Human)

Structure

Length:
386
Sequence:
MAAVETRVCETDGCSSEAKLQCPTCIKLGIQGSYFCSQECFKGSWATHKLLHKKAKDEKAKREVSSWTVEGDINTDPWAGYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMSQF
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm

Function

Function:
Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle.
Catalytic Activity:
Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
Cofactor:
COFACTOR: Name=Co(2+); Xref=ChEBI:CHEBI:48828;
Gene Ontology Go:
cytoplasm
cytosol
nucleus
aminopeptidase activity
metal ion binding
metalloexopeptidase activity
N-terminal protein amino acid modification
peptidyl-methionine modification
phototransduction, visible light
platelet aggregation
regulation of rhodopsin mediated signaling pathway
regulation of translation
rhodopsin mediated signaling pathway
Gene Ontology Biological Process:
N-terminal protein amino acid modification
peptidyl-methionine modification
phototransduction, visible light
platelet aggregation
regulation of rhodopsin mediated signaling pathway
regulation of translation
rhodopsin mediated signaling pathway
Gene Ontology Molecular Function:
aminopeptidase activity
metal ion binding
metalloexopeptidase activity
Gene Ontology Cellular Component:
cytoplasm
cytosol
nucleus
Keywords:
3D-structure
Acetylation
Aminopeptidase
Complete proteome
Cytoplasm
Hydrolase
Metal-binding
Protease
Reference proteome

Publication

PubMed ID:
7788527 14702039 15489334 19413330 21269460 24275569 25944712 16274222 16724298 17114291 16823043