Names & Taxonomy

Uniprot ID:
P52429
Entry Name:
DGKE_HUMAN
Status:
reviewed
Protein Names:
Diacylglycerol kinase epsilon (DAG kinase epsilon) (EC 2.7.1.107) (Diglyceride kinase epsilon) (DGK-epsilon)
Gene Names:
DGKE DAGK5
Gene Names Primary:
DGKE
Organism:
Homo sapiens (Human)

Structure

Length:
567
Sequence:
MEAERRPAPGSPSEGLFADGHLILWTLCSVLLPVFITFWCSLQRSRRQLHRRDIFRKSKHGWRDTDLFSQPTYCCVCAQHILQGAFCDCCGLRVDEGCLRKADKRFQCKEIMLKNDTKVLDAMPHHWIRGNVPLCSYCMVCKQQCGCQPKLCDYRCIWCQKTVHDECMKNSLKNEKCDFGEFKNLIIPPSYLTSINQMRKDKKTDYEVLASKLGKQWTPLIILANSRSGTNMGEGLLGEFRILLNPVQVFDVTKTPPIKALQLCTLLPYYSARVLVCGGDGTVGWVLDAVDDMKIKGQEKYIPQVAVLPLGTGNDLSNTLGWGTGYAGEIPVAQVLRNVMEADGIKLDRWKVQVTNKGYYNLRKPKEFTMNNYFSVGPDALMALNFHAHREKAPSLFSSRILNKAVYLFYGTKDCLVQECKDLNKKVELELDGERVALPSLEGIIVLNIGYWGGGCRLWEGMGDETYPLARHDDGLLEVVGVYGSFHCAQIQVKLANPFRIGQAHTVRLILKCSMMPMQVDGEPWAQGPCTVTITHKTHAMMLYFSGEQTDDDISSTSDQEDIKATE
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane

Function

Function:
Highly selective for arachidonate-containing species of diacylglycerol (DAG). May terminate signals transmitted through arachidonoyl-DAG or may contribute to the synthesis of phospholipids with defined fatty acid composition.
Catalytic Activity:
ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.
Gene Ontology Go:
cytoplasm
integral component of membrane
membrane
plasma membrane
ATP binding
diacylglycerol kinase activity
metal ion binding
blood coagulation
intracellular signal transduction
phospholipid biosynthetic process
platelet activation
protein kinase C-activating G-protein coupled receptor signaling pathway
Gene Ontology Biological Process:
blood coagulation
intracellular signal transduction
phospholipid biosynthetic process
platelet activation
protein kinase C-activating G-protein coupled receptor signaling pathway
Gene Ontology Molecular Function:
ATP binding
diacylglycerol kinase activity
metal ion binding
Gene Ontology Cellular Component:
cytoplasm
integral component of membrane
membrane
plasma membrane
Keywords:
ATP-binding
Alternative splicing
Complete proteome
Cytoplasm
Disease mutation
Hemolytic uremic syndrome
Kinase
Membrane
Metal-binding
Nucleotide-binding
Polymorphism
Reference proteome
Repeat
Transferase
Transmembrane
Transmembrane helix
Zinc
Zinc-finger

Publication

PubMed ID:
8626589 16625196 15489334 10571048 23274426 23542698 16959974