Names & Taxonomy
- Uniprot ID:
- P52429
- Entry Name:
- DGKE_HUMAN
- Status:
- reviewed
- Protein Names:
- Diacylglycerol kinase epsilon (DAG kinase epsilon) (EC 2.7.1.107) (Diglyceride kinase epsilon) (DGK-epsilon)
- Gene Names:
- DGKE DAGK5
- Gene Names Primary:
- DGKE
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 567
- Sequence:
- MEAERRPAPGSPSEGLFADGHLILWTLCSVLLPVFITFWCSLQRSRRQLHRRDIFRKSKHGWRDTDLFSQPTYCCVCAQHILQGAFCDCCGLRVDEGCLRKADKRFQCKEIMLKNDTKVLDAMPHHWIRGNVPLCSYCMVCKQQCGCQPKLCDYRCIWCQKTVHDECMKNSLKNEKCDFGEFKNLIIPPSYLTSINQMRKDKKTDYEVLASKLGKQWTPLIILANSRSGTNMGEGLLGEFRILLNPVQVFDVTKTPPIKALQLCTLLPYYSARVLVCGGDGTVGWVLDAVDDMKIKGQEKYIPQVAVLPLGTGNDLSNTLGWGTGYAGEIPVAQVLRNVMEADGIKLDRWKVQVTNKGYYNLRKPKEFTMNNYFSVGPDALMALNFHAHREKAPSLFSSRILNKAVYLFYGTKDCLVQECKDLNKKVELELDGERVALPSLEGIIVLNIGYWGGGCRLWEGMGDETYPLARHDDGLLEVVGVYGSFHCAQIQVKLANPFRIGQAHTVRLILKCSMMPMQVDGEPWAQGPCTVTITHKTHAMMLYFSGEQTDDDISSTSDQEDIKATE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- Highly selective for arachidonate-containing species of diacylglycerol (DAG). May terminate signals transmitted through arachidonoyl-DAG or may contribute to the synthesis of phospholipids with defined fatty acid composition.
- Catalytic Activity:
- ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.
- Gene Ontology Go:
- cytoplasm
integral component of membrane
membrane
plasma membrane
ATP binding
diacylglycerol kinase activity
metal ion binding
blood coagulation
intracellular signal transduction
phospholipid biosynthetic process
platelet activation
protein kinase C-activating G-protein coupled receptor signaling pathway - Gene Ontology Biological Process:
- blood coagulation
intracellular signal transduction
phospholipid biosynthetic process
platelet activation
protein kinase C-activating G-protein coupled receptor signaling pathway - Gene Ontology Molecular Function:
- ATP binding
diacylglycerol kinase activity
metal ion binding - Gene Ontology Cellular Component:
- cytoplasm
integral component of membrane
membrane
plasma membrane - Keywords:
- ATP-binding
Alternative splicing
Complete proteome
Cytoplasm
Disease mutation
Hemolytic uremic syndrome
Kinase
Membrane
Metal-binding
Nucleotide-binding
Polymorphism
Reference proteome
Repeat
Transferase
Transmembrane
Transmembrane helix
Zinc
Zinc-finger