Names & Taxonomy
- Uniprot ID:
- P51857
- Entry Name:
- AK1D1_HUMAN
- Status:
- reviewed
- Protein Names:
- 3-oxo-5-beta-steroid 4-dehydrogenase (EC 1.3.1.3) (Aldo-keto reductase family 1 member D1) (Delta(4)-3-ketosteroid 5-beta-reductase) (Delta(4)-3-oxosteroid 5-beta-reductase)
- Gene Names:
- AKR1D1 SRD5B1
- Gene Names Primary:
- AKR1D1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 326
- Sequence:
- MDLSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNVRFVELLMWRDHPEYPFHDEY
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4-cholesten-3-one can also act as substrates.
- Catalytic Activity:
- 5-beta-cholestan-3-one + NADP(+) = cholest-4-en-3-one + NADPH.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=2.7 uM for testosterone
- Enzyme Regulation:
- ENZYME REGULATION: Subject to inhibition by high substrate concentrations. Inhibited by testosterone concentrations above 10 uM.
- Active Site:
- ACT_SITE 58 58 Proton donor.
- Cross Reference Drug Bank:
- DB00548 DB01216
- Gene Ontology Go:
- cytosol
extracellular exosome
delta4-3-oxosteroid 5beta-reductase activity
steroid binding
androgen metabolic process
bile acid biosynthetic process
bile acid catabolic process
bile acid metabolic process
C21-steroid hormone metabolic process
cholesterol catabolic process
digestion
oxidation-reduction process
small molecule metabolic process - Gene Ontology Biological Process:
- androgen metabolic process
bile acid biosynthetic process
bile acid catabolic process
bile acid metabolic process
C21-steroid hormone metabolic process
cholesterol catabolic process
digestion
oxidation-reduction process
small molecule metabolic process - Gene Ontology Molecular Function:
- delta4-3-oxosteroid 5beta-reductase activity
steroid binding - Gene Ontology Cellular Component:
- cytosol
extracellular exosome - Keywords:
- 3D-structure
Alternative splicing
Bile acid catabolism
Complete proteome
Cytoplasm
Disease mutation
Intrahepatic cholestasis
Lipid degradation
Lipid metabolism
NADP
Oxidoreductase
Reference proteome
Steroid metabolism