Names & Taxonomy

Uniprot ID:
P51857
Entry Name:
AK1D1_HUMAN
Status:
reviewed
Protein Names:
3-oxo-5-beta-steroid 4-dehydrogenase (EC 1.3.1.3) (Aldo-keto reductase family 1 member D1) (Delta(4)-3-ketosteroid 5-beta-reductase) (Delta(4)-3-oxosteroid 5-beta-reductase)
Gene Names:
AKR1D1 SRD5B1
Gene Names Primary:
AKR1D1
Organism:
Homo sapiens (Human)

Structure

Length:
326
Sequence:
MDLSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNVRFVELLMWRDHPEYPFHDEY
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm.

Function

Function:
Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4-cholesten-3-one can also act as substrates.
Catalytic Activity:
5-beta-cholestan-3-one + NADP(+) = cholest-4-en-3-one + NADPH.
Kinetics:
BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=2.7 uM for testosterone
Enzyme Regulation:
ENZYME REGULATION: Subject to inhibition by high substrate concentrations. Inhibited by testosterone concentrations above 10 uM.
Active Site:
ACT_SITE 58 58 Proton donor.
Cross Reference Drug Bank:
DB00548 DB01216
Gene Ontology Go:
cytosol
extracellular exosome
delta4-3-oxosteroid 5beta-reductase activity
steroid binding
androgen metabolic process
bile acid biosynthetic process
bile acid catabolic process
bile acid metabolic process
C21-steroid hormone metabolic process
cholesterol catabolic process
digestion
oxidation-reduction process
small molecule metabolic process
Gene Ontology Biological Process:
androgen metabolic process
bile acid biosynthetic process
bile acid catabolic process
bile acid metabolic process
C21-steroid hormone metabolic process
cholesterol catabolic process
digestion
oxidation-reduction process
small molecule metabolic process
Gene Ontology Molecular Function:
delta4-3-oxosteroid 5beta-reductase activity
steroid binding
Gene Ontology Cellular Component:
cytosol
extracellular exosome
Keywords:
3D-structure
Alternative splicing
Bile acid catabolism
Complete proteome
Cytoplasm
Disease mutation
Intrahepatic cholestasis
Lipid degradation
Lipid metabolism
NADP
Oxidoreductase
Reference proteome
Steroid metabolism

Publication

PubMed ID:
7508385 11342103 14702039 12853948 12690205 15489334 21269460 24275569 18624455 19075558 18407998 19515843 18848863 22437839 12970144 15030995