Names & Taxonomy
- Uniprot ID:
- P51843
- Entry Name:
- NR0B1_HUMAN
- Status:
- reviewed
- Protein Names:
- Nuclear receptor subfamily 0 group B member 1 (DSS-AHC critical region on the X chromosome protein 1) (Nuclear receptor DAX-1)
- Gene Names:
- NR0B1 AHC DAX1
- Gene Names Primary:
- NR0B1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 470
- Sequence:
- MAGENHQWQGSILYNMLMSAKQTRAAPEAPETRLVDQCWGCSCGDEPGVGREGLLGGRNVALLYRCCFCGKDHPRQGSILYSMLTSAKQTYAAPKAPEATLGPCWGCSCGSDPGVGRAGLPGGRPVALLYRCCFCGEDHPRQGSILYSLLTSSKQTHVAPAAPEARPGGAWWDRSYFAQRPGGKEALPGGRATALLYRCCFCGEDHPQQGSTLYCVPTSTNQAQAAPEERPRAPWWDTSSGALRPVALKSPQVVCEAASAGLLKTLRFVKYLPCFQVLPLDQQLVLVRNCWASLLMLELAQDRLQFETVEVSEPSMLQKILTTRRRETGGNEPLPVPTLQHHLAPPAEARKVPSASQVQAIKCFLSKCWSLNISTKEYAYLKGTVLFNPDVPGLQCVKYIQGLQWGTQQILSEHTRMTHQGPHDRFIELNSTLFLLRFINANVIAELFFRPIIGTVSMDDMMLEMLCTKI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus
Function
- Function:
- Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity).
- Cross Reference Drug Bank:
- DB01234 DB00755
- Gene Ontology Go:
- cytoplasm
membrane
nucleoplasm
nucleus
polysomal ribosome
AF-2 domain binding
DNA binding
DNA hairpin binding
protein domain specific binding
protein homodimerization activity
RNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
sequence-specific DNA binding
steroid hormone receptor activity
steroid hormone receptor binding
transcription corepressor activity
transcription factor binding
adrenal gland development
gene expression
gonad development
hypothalamus development
intracellular receptor signaling pathway
Leydig cell differentiation
male gonad development
male sex determination
negative regulation of cell differentiation
negative regulation of intracellular steroid hormone receptor signaling pathway
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of transcription from RNA polymerase II promoter
negative regulation of transcription, DNA-templated
pituitary gland development
protein localization
response to immobilization stress
Sertoli cell differentiation
spermatogenesis
steroid biosynthetic process
transcription initiation from RNA polymerase II promoter - Gene Ontology Biological Process:
- adrenal gland development
gene expression
gonad development
hypothalamus development
intracellular receptor signaling pathway
Leydig cell differentiation
male gonad development
male sex determination
negative regulation of cell differentiation
negative regulation of intracellular steroid hormone receptor signaling pathway
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of transcription, DNA-templated
negative regulation of transcription from RNA polymerase II promoter
pituitary gland development
protein localization
response to immobilization stress
Sertoli cell differentiation
spermatogenesis
steroid biosynthetic process
transcription initiation from RNA polymerase II promoter - Gene Ontology Molecular Function:
- AF-2 domain binding
DNA binding
DNA hairpin binding
protein domain specific binding
protein homodimerization activity
RNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
sequence-specific DNA binding
steroid hormone receptor activity
steroid hormone receptor binding
transcription corepressor activity
transcription factor binding - Gene Ontology Cellular Component:
- cytoplasm
membrane
nucleoplasm
nucleus
polysomal ribosome - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Cytoplasm
Disease mutation
Nucleus
Receptor
Reference proteome
Repeat
Repressor
Transcription
Transcription regulation - Interacts With:
- P62508; Q13285; P35398