Names & Taxonomy

Uniprot ID:
P51793
Entry Name:
CLCN4_HUMAN
Status:
reviewed
Protein Names:
H(+)/Cl(-) exchange transporter 4 (Chloride channel protein 4) (ClC-4) (Chloride transporter ClC-4)
Gene Names:
CLCN4
Gene Names Primary:
CLCN4
Organism:
Homo sapiens (Human)

Structure

Length:
760
Sequence:
MVNAGAMSGSGNLMDFLDEPFPDVGTYEDFHTIDWLREKSRDTDRHRKITSKSKESIWEFIKSLLDAWSGWVVMLLIGLLAGTLAGVIDLAVDWMTDLKEGVCLSAFWYSHEQCCWTSNETTFEDRDKCPLWQKWSELLVNQSEGASAYILNYLMYILWALLFAFLAVSLVRVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLLIKTVTLVLVVSSGLSLGKEGPLVHVACCCGNFFSSLFSKYSKNEGKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGNSRLVLFYVEYHTPWYMAELFPFILLGVFGGLWGTLFIRCNIAWCRRRKTTRLGKYPVLEVIVVTAITAIIAYPNPYTRQSTSELISELFNDCGALESSQLCDYINDPNMTRPVDDIPDRPAGVGVYTAMWQLALALIFKIVVTIFTFGMKIPSGLFIPSMAVGAIAGRMVGIGVEQLAYHHHDWIIFRNWCRPGADCVTPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAVTSKWVADAFGKEGIYEAHIHLNGYPFLDVKDEFTHRTLATDVMRPRRGEPPLSVLTQDSMTVEDVETLIKETDYNGFPVVVSRDSERLIGFAQRRELILAIKNARQRQEGIVSNSIMYFTEEPPELPANSPHPLKLRRILNLSPFTVTDHTPMETVVDIFRKLGLRQCLVTRSGRLLGIITKKDVLRHMAQMANQDPESIMFN
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Early endosome membrane
Intramembrane:
INTRAMEM 183 190 Helical.

Function

Function:
Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons.
Gene Ontology Go:
early endosome membrane
endosome membrane
integral component of membrane
late endosome membrane
antiporter activity
ATP binding
chloride channel activity
voltage-gated chloride channel activity
chloride transmembrane transport
chloride transport
ion transmembrane transport
regulation of anion transmembrane transport
transmembrane transport
transport
Gene Ontology Biological Process:
chloride transmembrane transport
chloride transport
ion transmembrane transport
regulation of anion transmembrane transport
transmembrane transport
transport
Gene Ontology Molecular Function:
antiporter activity
ATP binding
chloride channel activity
voltage-gated chloride channel activity
Gene Ontology Cellular Component:
early endosome membrane
endosome membrane
integral component of membrane
late endosome membrane
Keywords:
ATP-binding
Alternative splicing
Antiport
CBS domain
Chloride
Complete proteome
Endosome
Ion transport
Membrane
Nucleotide-binding
Reference proteome
Repeat
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
8069296 10564087 14702039 15772651 15489334 18063579