Names & Taxonomy
- Uniprot ID:
- P51790
- Entry Name:
- CLCN3_HUMAN
- Status:
- reviewed
- Protein Names:
- H(+)/Cl(-) exchange transporter 3 (Chloride channel protein 3) (ClC-3) (Chloride transporter ClC-3)
- Gene Names:
- CLCN3
- Gene Names Primary:
- CLCN3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 818
- Sequence:
- MESEQLFHRGYYRNSYNSITSASSDEELLDGAGVIMDFQTSEDDNLLDGDTAVGTHYTMTNGGSINSSTHLLDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWEMTKSLYDAWSGWLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETTFEERDKCPQWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLFPKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSINPFGNSRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKSTKFGKYPVLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNASKIVDDIPDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRIVGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRPRRNDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIESARKKQEGIVGSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDILRHMAQTANQDPASIMFN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform 1: Early endosome membrane
- Intramembrane:
- INTRAMEM 241 248 Helical.
Function
- Function:
- Mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could help neuronal cells to establish short-term memory.
- Gene Ontology Go:
- apical plasma membrane
cell surface
cytoplasmic vesicle
early endosome
early endosome membrane
external side of plasma membrane
Golgi apparatus
Golgi membrane
integral component of membrane
late endosome
late endosome membrane
membrane
phagocytic vesicle
plasma membrane
secretory granule
specific granule
synaptic vesicle
transport vesicle membrane
vesicle membrane
antiporter activity
ATP binding
chloride channel activity
PDZ domain binding
protein heterodimerization activity
protein homodimerization activity
voltage-gated chloride channel activity
volume-sensitive chloride channel activity
chloride transmembrane transport
endosomal lumen acidification
ion transmembrane transport
negative regulation of cell volume
regulation of pH
transmembrane transport
transport - Gene Ontology Biological Process:
- chloride transmembrane transport
endosomal lumen acidification
ion transmembrane transport
negative regulation of cell volume
regulation of pH
transmembrane transport
transport - Gene Ontology Molecular Function:
- antiporter activity
ATP binding
chloride channel activity
PDZ domain binding
protein heterodimerization activity
protein homodimerization activity
voltage-gated chloride channel activity
volume-sensitive chloride channel activity - Gene Ontology Cellular Component:
- apical plasma membrane
cell surface
cytoplasmic vesicle
early endosome
early endosome membrane
external side of plasma membrane
Golgi apparatus
Golgi membrane
integral component of membrane
late endosome
late endosome membrane
membrane
phagocytic vesicle
plasma membrane
secretory granule
specific granule
synaptic vesicle
transport vesicle membrane
vesicle membrane - Keywords:
- ATP-binding
Alternative splicing
Antiport
CBS domain
Chloride
Complete proteome
Cytoplasmic vesicle
Endosome
Glycoprotein
Golgi apparatus
Ion transport
Membrane
Nucleotide-binding
Reference proteome
Repeat
Transmembrane
Transmembrane helix
Transport