Names & Taxonomy
- Uniprot ID:
- P51681
- Entry Name:
- CCR5_HUMAN
- Status:
- reviewed
- Protein Names:
- C-C chemokine receptor type 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5) (CHEMR13) (HIV-1 fusion coreceptor) (CD antigen CD195)
- Gene Names:
- CCR5 CMKBR5
- Gene Names Primary:
- CCR5
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 352
- Sequence:
- MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.
- Cross Reference Drug Bank:
- DB04835
- Gene Ontology Go:
- cell surface
cytoplasm
endosome
external side of plasma membrane
integral component of plasma membrane
plasma membrane
actin binding
C-C chemokine binding
C-C chemokine receptor activity
chemokine (C-C motif) ligand 5 binding
chemokine receptor activity
coreceptor activity
phosphatidylinositol phospholipase C activity
virus receptor activity
calcium ion transport
calcium-mediated signaling
cell surface receptor signaling pathway
cell-cell signaling
cellular defense response
cellular response to lipopolysaccharide
chemokine-mediated signaling pathway
chemotaxis
dendritic cell chemotaxis
entry into host cell
G-protein coupled receptor signaling pathway
immune response
inflammatory response
MAPK cascade
positive regulation of cytosolic calcium ion concentration
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
response to cholesterol
signaling
viral process - Gene Ontology Biological Process:
- calcium ion transport
calcium-mediated signaling
cell-cell signaling
cell surface receptor signaling pathway
cellular defense response
cellular response to lipopolysaccharide
chemokine-mediated signaling pathway
chemotaxis
dendritic cell chemotaxis
entry into host cell
G-protein coupled receptor signaling pathway
immune response
inflammatory response
MAPK cascade
positive regulation of cytosolic calcium ion concentration
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
response to cholesterol
signaling
viral process - Gene Ontology Molecular Function:
- actin binding
C-C chemokine binding
C-C chemokine receptor activity
chemokine (C-C motif) ligand 5 binding
chemokine receptor activity
coreceptor activity
phosphatidylinositol phospholipase C activity
virus receptor activity - Gene Ontology Cellular Component:
- cell surface
cytoplasm
endosome
external side of plasma membrane
integral component of plasma membrane
plasma membrane - Keywords:
- 3D-structure
Cell membrane
Complete proteome
Diabetes mellitus
Disulfide bond
G-protein coupled receptor
Glycoprotein
Host cell receptor for virus entry
Host-virus interaction
Lipoprotein
Membrane
Palmitate
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Sulfation
Transducer
Transmembrane
Transmembrane helix - Interacts With:
- P13236; P13501; P01730