Names & Taxonomy
- Uniprot ID:
- P51677
- Entry Name:
- CCR3_HUMAN
- Status:
- reviewed
- Protein Names:
- C-C chemokine receptor type 3 (C-C CKR-3) (CC-CKR-3) (CCR-3) (CCR3) (CKR3) (Eosinophil eotaxin receptor) (CD antigen CD193)
- Gene Names:
- CCR3 CMKBR3
- Gene Names Primary:
- CCR3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 355
- Sequence:
- MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.
- Gene Ontology Go:
- integral component of plasma membrane
plasma membrane
C-C chemokine receptor activity
chemokine receptor activity
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
cell adhesion
cellular defense response
chemotaxis
inflammatory response
positive regulation of angiogenesis
positive regulation of cytosolic calcium ion concentration
positive regulation of endothelial cell proliferation
viral process - Gene Ontology Biological Process:
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
cell adhesion
cellular defense response
chemotaxis
inflammatory response
positive regulation of angiogenesis
positive regulation of cytosolic calcium ion concentration
positive regulation of endothelial cell proliferation
viral process - Gene Ontology Molecular Function:
- C-C chemokine receptor activity
chemokine receptor activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
plasma membrane - Keywords:
- Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Host-virus interaction
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix - Interacts With:
- P51671