Names & Taxonomy
- Uniprot ID:
- P51649
- Entry Name:
- SSDH_HUMAN
- Status:
- reviewed
- Protein Names:
- Succinate-semialdehyde dehydrogenase, mitochondrial (EC 1.2.1.24) (Aldehyde dehydrogenase family 5 member A1) (NAD(+)-dependent succinic semialdehyde dehydrogenase)
- Gene Names:
- ALDH5A1 SSADH
- Gene Names Primary:
- ALDH5A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 535
- Sequence:
- MATCIWLRSCGARRLGSTFPGCRLRPRAGGLVPASGPAPGPAQLRCYAGRLAGLSAALLRTDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVCYGGL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion.
Function
- Function:
- Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
- Pathway:
- Amino-acid degradation; 4-aminobutanoate degradation.
- Catalytic Activity:
- Succinate semialdehyde + NAD(+) + H(2)O = succinate + NADH.
- Enzyme Regulation:
- ENZYME REGULATION: Redox-regulated. Inhibited under oxydizing conditions. Inhibited by hydrogen peroxide H(2)O(2).
- Active Site:
- ACT_SITE 306 306 Proton acceptor.
- Cross Reference Drug Bank:
- DB00534 DB00139 DB00313
- Gene Ontology Go:
- mitochondrial matrix
mitochondrion
presynapse
aldehyde dehydrogenase (NAD) activity
carboxylic acid binding
NAD binding
protein homodimerization activity
succinate-semialdehyde dehydrogenase (NAD+) activity
succinate-semialdehyde dehydrogenase activity
acetate metabolic process
central nervous system development
galactosylceramide metabolic process
gamma-aminobutyric acid catabolic process
glucose metabolic process
glucosylceramide metabolic process
glutamate metabolic process
glutamine metabolic process
glutathione metabolic process
glycerophospholipid metabolic process
neurotransmitter catabolic process
neurotransmitter secretion
post-embryonic development
protein homotetramerization
respiratory electron transport chain
short-chain fatty acid metabolic process
succinate metabolic process
synaptic transmission - Gene Ontology Biological Process:
- acetate metabolic process
central nervous system development
galactosylceramide metabolic process
gamma-aminobutyric acid catabolic process
glucose metabolic process
glucosylceramide metabolic process
glutamate metabolic process
glutamine metabolic process
glutathione metabolic process
glycerophospholipid metabolic process
neurotransmitter catabolic process
neurotransmitter secretion
post-embryonic development
protein homotetramerization
respiratory electron transport chain
short-chain fatty acid metabolic process
succinate metabolic process
synaptic transmission - Gene Ontology Molecular Function:
- aldehyde dehydrogenase (NAD) activity
carboxylic acid binding
NAD binding
protein homodimerization activity
succinate-semialdehyde dehydrogenase (NAD+) activity
succinate-semialdehyde dehydrogenase activity - Gene Ontology Cellular Component:
- mitochondrial matrix
mitochondrion
presynapse - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
Disease mutation
Disulfide bond
Mitochondrion
NAD
Oxidoreductase
Phosphoprotein
Polymorphism
Reference proteome
Transit peptide