Names & Taxonomy

Uniprot ID:
P51570
Entry Name:
GALK1_HUMAN
Status:
reviewed
Protein Names:
Galactokinase (EC 2.7.1.6) (Galactose kinase)
Gene Names:
GALK1 GALK
Gene Names Primary:
GALK1
Organism:
Homo sapiens (Human)

Structure

Length:
392
Sequence:
MAALRQPQVAELLAEARRAFREEFGAEPELAVSAPGRVNLIGEHTDYNQGLVLPMALELMTVLVGSPRKDGLVSLLTTSEGADEPQRLQFPLPTAQRSLEPGTPRWANYVKGVIQYYPAAPLPGFSAVVVSSVPLGGGLSSSASLEVATYTFLQQLCPDSGTIAARAQVCQQAEHSFAGMPCGIMDQFISLMGQKGHALLIDCRSLETSLVPLSDPKLAVLITNSNVRHSLASSEYPVRRRQCEEVARALGKESLREVQLEELEAARDLVSKEGFRRARHVVGEIRRTAQAAAALRRGDYRAFGRLMVESHRSLRDDYEVSCPELDQLVEAALAVPGVYGSRMTGGGFGGCTVTLLEASAAPHAMRHIQEHYGGTATFYLSQAADGAKVLCL
Proteomes:
UP000005640

Function

Function:
Major enzyme for galactose metabolism.
Pathway:
Carbohydrate metabolism; galactose metabolism.
Catalytic Activity:
ATP + alpha-D-galactose = ADP + alpha-D-galactose 1-phosphate.
Active Site:
ACT_SITE 186 186 Proton acceptor.
Gene Ontology Go:
cytoplasm
cytosol
extracellular exosome
membrane
ATP binding
galactokinase activity
galactose binding
carbohydrate metabolic process
galactitol metabolic process
galactose catabolic process
galactose metabolic process
glycolytic process from galactose
small molecule metabolic process
Gene Ontology Biological Process:
carbohydrate metabolic process
galactitol metabolic process
galactose catabolic process
galactose metabolic process
glycolytic process from galactose
small molecule metabolic process
Gene Ontology Molecular Function:
ATP binding
galactokinase activity
galactose binding
Gene Ontology Cellular Component:
cytoplasm
cytosol
extracellular exosome
membrane
Keywords:
3D-structure
ATP-binding
Alternative splicing
Carbohydrate metabolism
Cataract
Complete proteome
Direct protein sequencing
Disease mutation
Galactose metabolism
Kinase
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Transferase

Publication

PubMed ID:
7670469 8908517 14702039 16625196 15489334 7542884 21269460 24275569 25944712 15590630 10521295 10790206 11231902 11139256 12694189 12942049 15024738